Recombinant FSHR 抗体
Quick Overview for Recombinant FSHR 抗体 (ABIN7543214)
抗原
See all FSHR 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- Anti-FSH receptor [9H11], Rabbit IgG, lambda
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特异性
- This antibody binds human and mice FSH receptor. FSH receptor is a G protein-coupled receptor for follitropin, the follicle-stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways.
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交叉反应
- 小鼠
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产品特性
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Original Species of Ab: Mouse
Original Format of Ab: IgG2a
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纯化方法
- Protein A affinity purified
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免疫原
- The original antibody was generated by immunizing Balb/c mice with an optimized DNA construct encoding human FSHR.
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亚型
- IgG lambda
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anti-Follicle Stimulating Hormone Receptor (FSHR) (AA 201-300) antibody
FSHR 适用: 人, 小鼠, 大鼠 WB, ELISA, FACS, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Follicle Stimulating Hormone Receptor (FSHR) (AA 631-695) antibodyFSHR 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Follicle Stimulating Hormone Receptor (FSHR) (AA 18-366) antibodyFSHR 适用: 人 ELISA, FACS 宿主: 小鼠 Monoclonal 3D5G9 unconjugated
anti-Follicle Stimulating Hormone Receptor (FSHR) (AA 21-100) antibodyFSHR 适用: 人, 小鼠, 大鼠 WB, FACS, IF (cc), IF (p), ICC, IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Follicle Stimulating Hormone Receptor (FSHR) (AA 18-120) antibodyFSHR 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Follicle Stimulating Hormone Receptor (FSHR) (N-Term) antibodyFSHR 适用: 人, 猴 IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Follicle Stimulating Hormone Receptor (FSHR) (N-Term) antibodyFSHR 适用: 人, 大鼠, 猴, Cow, Pig, 绵羊, Bat, 山羊, 马, 兔 IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Follicle Stimulating Hormone Receptor (FSHR) antibodyFSHR 适用: 人 IHC, StM 宿主: 小鼠 Monoclonal FSHR-1400 unconjugated
anti-Follicle Stimulating Hormone Receptor (FSHR) antibodyFSHR 适用: 人 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Follicle Stimulating Hormone Receptor (FSHR) (AA 278-327) antibodyFSHR 适用: 人 IHC, ELISA, IF, IHC (p) 宿主: 兔 Polyclonal unconjugated
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应用备注
- To test if the antibody dependent cellular cytotoxicity elicited by the mouse version of this antibody translated into an in vivo anti-tumor effect, mice were challenged with IDS -Defl29/Vegf-a-Fshr and treated with the mouse version of this antibody. The antibody was able to delay tumor progression. To further characterize the antibody its ability to bind cells expressing human and mouse FHSR, flow cytometry was performed using the mouse version of this antibody on A20 cells, ID8- Defl29/Vegf-a-Fshr cells and human ovarian cancer cell lines like Caov3, OVCAR3, TOV21 G and PC3 with physiological levels of FSHR. Isotype analysis of the antibody was done using ELISA. Finally immunofluorescence was performed on 293T cells transduced with human or murine FSHR using the mouse version of this antibody (WO2020033797).
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说明
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This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse IgG2a format for improved compatibility with existing reagents assays and techniques.
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限制
- 仅限研究用
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浓度
- 1 mg/mL
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缓冲液
- PBS with 0.02 % Proclin 300.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.
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- FSHR (Follicle Stimulating Hormone Receptor (FSHR))
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别名
- FSH receptor
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背景
- FSHR, FSH-R, Follicle-stimulating hormone receptor, Follitropin receptor, LGR1
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UniProt
- P23945
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途径
- Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Regulation of Hormone Metabolic Process, Platelet-derived growth Factor Receptor Signaling
抗原
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