FSHR 抗体 (Extracellular, N-Term)
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Quick Overview for FSHR 抗体 (Extracellular, N-Term) (ABIN7043134)
抗原
See all FSHR 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 128-140, Extracellular, N-Term
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原理
- A Rabbit Polyclonal Antibody to FSH Receptor
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交叉反应
- 人, 大鼠
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预测反应
- Mouse,human - 12,13 amino acid residues identical
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产品特性
- Anti-FSHR (extracellular) Antibody is directed against an extracellular epitope of the rat FSH receptor. Anti-FSHR (extracellular) Antibody (ABIN7043134, ABIN7044277 and ABIN7044278) can be used in western blot and live cell imaging applications. It has been designed to recognize the FSH receptor from rat, mouse and human samples.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
- (C)SNTGIKHLPAVHK, corresponding to amino acid residues 128-140 of rat FSHR
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亚型
- IgG
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anti-Follicle Stimulating Hormone Receptor (FSHR) (AA 201-300) antibody
FSHR 适用: 人, 小鼠, 大鼠 WB, ELISA, FACS, IF (p), IF (cc), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Follicle Stimulating Hormone Receptor (FSHR) (AA 631-695) antibodyFSHR 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Follicle Stimulating Hormone Receptor (FSHR) (AA 18-366) antibodyFSHR 适用: 人 ELISA, FACS 宿主: 小鼠 Monoclonal 3D5G9 unconjugated
anti-Follicle Stimulating Hormone Receptor (FSHR) (AA 21-100) antibodyFSHR 适用: 人, 小鼠, 大鼠 WB, FACS, ICC, IF (p), IF (cc), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Follicle Stimulating Hormone Receptor (FSHR) (AA 18-120) antibodyFSHR 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Follicle Stimulating Hormone Receptor (FSHR) antibodyFSHR 适用: 人 IHC 宿主: 小鼠 Monoclonal FSHR-1400 unconjugated
anti-Follicle Stimulating Hormone Receptor (FSHR) (N-Term) antibodyFSHR 适用: 人, 猴 IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Follicle Stimulating Hormone Receptor (FSHR) (N-Term) antibodyFSHR 适用: 人, 大鼠, 猴, 绵羊, Cow, Pig, Bat, 山羊, 马, 兔 IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Follicle Stimulating Hormone Receptor (FSHR) antibodyFSHR 适用: 人 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Follicle Stimulating Hormone Receptor (FSHR) (AA 278-327) antibodyFSHR 适用: 人 IHC, IF, ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated
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应用备注
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WB: 1:200
FC: The optimal concentration should be determined by the user
ICC: 1:25
IHC: 1:200
IP: The optimal concentration should be determined by the user
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说明
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Negative Control: (ABIN7235325)
Blocking Peptide: (ABIN7235325)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.
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浓度
- 0.8 mg/mL
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缓冲液
- PBS pH 7.4, 1 % BSA with 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C
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- FSHR (Follicle Stimulating Hormone Receptor (FSHR))
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别名
- FSHR
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背景
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Synonyms: FSH receptor, Follicle-stimulating hormone receptor, Follitropin receptor, FSHRO
Description: FSH (follicle stimulating hormone) is the central hormone of mammalian reproduction, necessary for gonadal development and maturation at puberty and for gamete production during the fertile phase of life1. Together with LH, this gonadotropin is produced and secreted by the pituitary gland as a highly heterogeneous glycoprotein2. The FSH receptor belongs to the family of G-protein coupled receptors, complex transmembrane proteins characterized by seven hydrophobic helices inserted in the plasma membrane and by intracellular and extracellular domains of variable dimensions depending on the type of ligand3. The intracellular portion of the FSH receptor is coupled to a Gs protein and, upon receptor activation by the hormonal interaction with the extracellular domain it initiates a cascade of events that ultimately leads to the specific biological effects of the gonadotropin.FSH acts by binding to specific receptors, localized exclusively in the gonads. The FSH receptor is expressed by two cell types of the gonad, namely Sertoli cells in the testis, and granulosa cells in the ovarian follicle4.Mutations of FSHR may cause primary or secondary amenorrhea, infertility, premature ovarian failure (POF) and ovarian hyperstimulation syndrome (OHSS)5. Mutations of FSHR may also play a role in the development of granulosa cell tumors of ovaries6.
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基因ID
- 25449
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NCBI登录号
- NM_000145
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UniProt
- P20395
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途径
- Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Regulation of Hormone Metabolic Process, Platelet-derived growth Factor Receptor Signaling
抗原
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