Recombinant GM2 Ganglioside 抗体
The 兔 Chimeric anti-GM2 Ganglioside antibody (Clone KM966) (ABIN7543165) specifically detects GM2 Ganglioside in ELISA, IF, FACS 和 ICC.
The antibody is reactive with 人 samples.
产品编号 ABIN7543165
发货至:
中国
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Contact Info
Our Local Distributor
中国
北京 101111
北京 101111
No. 88 KeChuang 6th Street
Beijing Economic Technological Development Area
Room 801-803
Quick Overview for Recombinant GM2 Ganglioside 抗体 (ABIN7543165)
抗原
GM2 Ganglioside
抗体类型
Recombinant Antibody
适用
人
宿主
兔
克隆类型
Chimeric
标记
非结合性
应用范围
ELISA, Immunofluorescence (IF), Flow Cytometry (FACS), Immunocytochemistry (ICC)
克隆位点
KM966
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原理
- Anti-GM2 ganglioside [KM966], Rabbit IgG, kappa
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特异性
- This antibody recognizes and binds ganglioside GM2.
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产品特性
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Original Species of Ab: Human
Original Format of Ab: IgG1
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纯化方法
- Protein A affinity purified
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免疫原
- This chimeric antibody was generated by cloning the variable heavy and light chain sequences of murine parent antibody KM696 (IgM) and expressing it as a mouse/human IgG1. The parent antibody was raised against human GM2.
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亚型
- IgG kappa
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anti-GM2 Ganglioside antibody
适用: 人 ELISA, IHC, Dep, TLC Overlay 宿主: 兔 Chimeric L55-81 unconjugated Recombinant Antibody
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应用备注
- This antibody shows antitumor activity both in vitro and in vivo. Chimeric KM966 markedly suppressed the establishment of f human tumor xenografts in nude mice. Indirect immunofluorescence staining of tumor cell lines with the chimeric KM966 revealed that the antigen was expressed in substantial amounts on pulmonary tumor cells and leukemia cells as well as neuroectodermal origin tumor cells. This antibody also reacts with GM2 in an ELISA and also can be used for the identification of tumor cells expressing GM2 via flow cytometry (PMID: 8137257). The effect of chimeric antibody KM966 on GM2 expressing human solid tumors in vivo was done in PMID: 10417777. This antibody was also used in the immunocytochemical staining of cultured skin fibroblast of patients with GM2-gangliosidosis (PMID: 28417072). Humanized versions of this antibody KM8966, KM8967, KM8969 and KM8970 are available on request.
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说明
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This chimeric rabbit antibody was made using the variable domain sequences of the original Human IgG1 format, for improved compatibility with existing reagents, assays and techniques.
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限制
- 仅限研究用
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浓度
- 1 mg/mL
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缓冲液
- PBS with 0.02 % Proclin 300.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.
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- GM2 Ganglioside
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背景
- GM2
抗原
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