Recombinant IL2 Receptor beta 抗体
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Quick Overview for Recombinant IL2 Receptor beta 抗体 (ABIN7543150)
抗原
See all IL2 Receptor beta (IL2RB) 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- Anti-IL-2R Beta chain [Mik-beta 1], Rabbit IgG, kappa
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特异性
- This antibody recognizes and binds the beta chain of the IL-2 receptor and completely inhibits the IL-2 binding to the beta chain. The beta subunit is involved in receptor mediated endocytosis and transduction of the mitogenic signals of IL2.
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产品特性
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Original Species of Ab: Mouse
Original Format of Ab: IgG2a
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纯化方法
- Protein A affinity purified
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免疫原
- The original antibody was generated by immunizing BLAB/c mice with YTS cells, a human NK-like cell line that highly expresses the human IL-2R beta chain as immunogen.
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亚型
- IgG kappa
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anti-Interleukin 2 Receptor, beta (IL2RB) (AA 27-240) antibody
IL2RB 适用: 人 FACS, ELISA 宿主: 小鼠 Monoclonal 1G11C6 unconjugated
anti-Interleukin 2 Receptor, beta (IL2RB) antibodyIL2RB 适用: 人 FACS, IP, Func 宿主: 小鼠 Monoclonal TU27 unconjugated
anti-Interleukin 2 Receptor, beta (IL2RB) antibodyIL2RB 适用: 人 FACS, IP 宿主: 小鼠 Monoclonal TU27 unconjugated
anti-Interleukin 2 Receptor, beta (IL2RB) antibody (APC)IL2RB 适用: 人 FACS 宿主: 小鼠 Monoclonal TU27 APC
anti-Interleukin 2 Receptor, beta (IL2RB) (AA 27-240) antibodyIL2RB 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Interleukin 2 Receptor, beta (IL2RB) (Tyr364) antibodyIL2RB 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Interleukin 2 Receptor, beta (IL2RB) (N-Term) antibodyIL2RB 适用: 小鼠, 人 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Interleukin 2 Receptor, beta (IL2RB) (AA 1-551) antibodyIL2RB 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Interleukin 2 Receptor, beta (IL2RB) (AA 1-551) antibodyIL2RB 适用: 人 WB, FACS 宿主: 小鼠 Polyclonal unconjugated
anti-Interleukin 2 Receptor, beta (IL2RB) (AA 501-551) antibodyIL2RB 适用: 小鼠, 人 WB, FACS, ELISA, IF (p), IF (cc), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
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应用备注
- Mik-beta 1 inhibited binding of iodine labelled IL-2 to YTS cells in a dose dependent manner. Mik-beta 1 also successfully immunoprecipitated beta chain of the IL-2R from radio iodinated YTS extract. Biotinylated Mik-beta 1 also efficiently competes with IL-2 for binding to solubilized beta chain. Flow cytometry was used to study the cellular disctribution of beta chain, as determined by mik-beta 1 staining. This antibody completely inhibited IL-2 dependent T cell growth in presence of anti-Tac. Two-color flow cytometric analysis using anti-beta chain mAbs clearly showed that approximately 10 % of peripheral blood lymphocytes manifest the beta chain and that this population is mainly composed of Leu-19+ NK cells (PMID: 2467293). Mik beta 1 antibody acts synergistically with humanized anti-Tac to prevent IL-2-induced proliferation of activated T cells (PMID: 8335891). A recombinant single chain immunotoxin of Mik-beta 1 and Pseudomonas derived exotoxin PE40 was selectively cytotoxic for cells expressing high levels of IL-2R beta (p75) subunit (PMID: 1401913).
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说明
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This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse IgG2a format, for improved compatibility with existing reagents, assays and techniques.
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限制
- 仅限研究用
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浓度
- 1 mg/mL
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缓冲液
- PBS with 0.02 % Proclin 300.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.
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- IL2 Receptor beta (IL2RB) (Interleukin 2 Receptor, beta (IL2RB))
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别名
- IL-2R Beta chain
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背景
- CD122, IL-2R, IL2Rβ, IL-2RB, p70-75, p75, Interleukin-2 receptor subunit beta, IL-2 receptor subunit beta, IL-2R subunit beta, High affinity IL-2 receptor subunit beta, Interleukin-15 receptor subunit beta, Mik-β1
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UniProt
- P14784
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途径
- JAK/STAT Signaling, Growth Factor Binding
抗原
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