FGFR2 抗体 (C-Term)
Quick Overview for FGFR2 抗体 (C-Term) (ABIN7540624)
抗原
See all FGFR2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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Supplier Product No.
- 600-401-mm7s
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Supplier
- Rockland
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原理
- FGFR2 Antibody
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交叉反应 （详细）
- This affinity purified antibody is directed against human FGFR2.
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纯化方法
- The antibody was affinity purified from monospecific antiserum by immunoaffinity purification.
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过滤
- Sterile filtered
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免疫原
- Anti-FGFR2 antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to a C-terminal portion of human FGFR2 conjugated to Keyhole Limpet Hemocyanin (KLH).
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亚型
- IgG
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anti-Fibroblast Growth Factor Receptor 2 (FGFR2) (AA 1-100) antibody
FGFR2 适用: 人 IHC 宿主: 兔 Polyclonal unconjugated
anti-Fibroblast Growth Factor Receptor 2 (FGFR2) (AA 22-51), (N-Term) antibodyFGFR2 适用: 人, 小鼠 WB, FACS, IF, IHC (p) 宿主: 兔 Polyclonal RB01567 unconjugated
anti-Fibroblast Growth Factor Receptor 2 (FGFR2) (AA 621-723) antibodyFGFR2 适用: 人 WB, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 1G3 unconjugated
anti-Fibroblast Growth Factor Receptor 2 (FGFR2) (AA 7-37) antibodyFGFR2 适用: 人, 小鼠, 大鼠, 灵长类 WB, IHC, ELISA, FACS, IF 宿主: 兔 Polyclonal unconjugated
anti-Fibroblast Growth Factor Receptor 2 (FGFR2) (AA 245-345) antibodyFGFR2 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Fibroblast Growth Factor Receptor 2 (FGFR2) antibodyFGFR2 适用: 人 WB, FACS, IF, IHC (p) 宿主: 兔 Polyclonal RB17696 unconjugated
anti-Fibroblast Growth Factor Receptor 2 (FGFR2) (AA 21-120) antibodyFGFR2 适用: 人, 小鼠, 大鼠 ELISA, FACS, IHC (p), ICC, IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Fibroblast Growth Factor Receptor 2 (FGFR2) (C-Term) antibodyFGFR2 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Fibroblast Growth Factor Receptor 2 (FGFR2) (AA 7-37), (N-Term) antibodyFGFR2 适用: 人 WB, FACS, IF 宿主: 兔 Polyclonal RB15689 unconjugated
anti-Fibroblast Growth Factor Receptor 2 (FGFR2) (AA 794-821) antibodyFGFR2 适用: 人 WB, IHC, ELISA, FACS, IF 宿主: 兔 Polyclonal unconjugated
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应用备注
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ELISA_Dilution: 1:10,000 - 1:50,000
Immunohistochemistry_Dilution: 1:100-1:200
IF_Microscopy_Dilution: 5-10 μg/mL
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说明
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Anti-FGFR2 Antibody has been tested in ELISA, IF, and IHC. Positive control used: U-20S in immunofluorescence and mouse spleen and gallbladder in immunohistochemistry.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
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Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
Stabilizer: None
Preservative: 0.01 % (w/v) Sodium Azide -
储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store vial at -20° C or below prior to opening. This vial contains a relatively low volume of reagent (25 μL). To minimize loss of volume dilute 1:10 by adding 225 μL of the buffer stated above directly to the vial. Recap, mix thoroughly and briefly centrifuge to collect the volume at the bottom of the vial. Use this intermediate dilution when calculating final dilutions as recommended below. Store the vial at -20°C or below after dilution. Avoid cycles of freezing and thawing.
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有效期
- 12 months
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- FGFR2 (Fibroblast Growth Factor Receptor 2 (FGFR2))
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别名
- FGFR2
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背景
- Rabbit Anti-Fibroblast Growth Factor Receptor 2 Antibody, Rabbit Anti-FGFR2 Antibody, Keratinocyte Growth Factor Receptor, Bacteria-Expressed Kinase, KGFR, BEK, Protein Tyrosine Kinase Receptor Like 14, BEK Fibroblast Growth Factor Receptor, Craniofacial Dysostosis 1, Jackson-Weiss Syndrome, Pfeiffer Syndrome, Crouzon Syndrome, CD332 Antigen, EC 2.7.10.1, FGFR-2, BFR-1, CD332, K-SAM, K-Sam, BBDS, CEK3, ECT1, TK14, TK25, CFD1, KSAM, JWS,FGFR2 (Fibroblast Growth Factor Receptor 2) are tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and are involved in a wide array of pathways known to play a significant role in cancer, angiogenesis, wound healing, cell migration, neural outgrowth and embryonic development. Phosphorylates PLCG1, FRS2 and PAK4. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. FGFR2 signaling is down-regulated by ubiquitination, internalization and degradation. The mechanisms by which FGFR can be misregulated vary between cancers. Amplification of the receptors has been observed in lung and breast cancers, coding mutations and deletions have been seen in many cancers, and more recently, FGFR fusions that lead to pathway activation have been demonstrated to have oncogenic potential across multiple cancer types. Anti-FGFR2 Antibody is useful for researchers interested in lung cancer research, crouzon syndrome, Pfeiffer syndrome, Craniosynostosis, bone and skin abnormalities, ERK Signaling, and Akt Signaling.
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基因ID
- 2263
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NCBI登录号
- NP_000132
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UniProt
- P21802
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途径
- RTK signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development, Growth Factor Binding
抗原
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