Menin 抗体 (C-Term)
Quick Overview for Menin 抗体 (C-Term) (ABIN7540527)
抗原
See all Menin (MEN1) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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Supplier Product No.
- 200-901-mj8s
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Supplier
- Rockland
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原理
- Anti-MEN1 Antibody
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交叉反应 （详细）
- This affinity purified antibody is directed against human Menin1.
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纯化方法
- This product is an IgY fraction antibody purified from monospecific chicken egg yolks by a multi-step process which includes selective precipitation and salt fractionation followed by extensive dialysis against the buffer stated above.
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过滤
- Sterile filtered
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免疫原
- Anti-Menin1 antibody was prepared from eggs of chickens laid after repeated immunizations with a synthetic peptide corresponding to a C-Terminal portion of human MEN1 conjugated to Keyhole Limpet Hemocyanin (KLH).
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亚型
- IgG
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anti-Multiple Endocrine Neoplasia 1 (MEN1) (AA 392-554) antibody
MEN1 适用: 人 ELISA, IHC, FACS 宿主: 小鼠 Monoclonal 7D3E10 unconjugated
anti-Multiple Endocrine Neoplasia 1 (MEN1) (AA 501-615) antibodyMEN1 适用: 人, 小鼠, 大鼠 ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Multiple Endocrine Neoplasia 1 (MEN1) (AA 219-395) antibodyMEN1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Multiple Endocrine Neoplasia 1 (MEN1) (AA 1-575) antibodyMEN1 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Multiple Endocrine Neoplasia 1 (MEN1) (AA 1-575) antibodyMEN1 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Multiple Endocrine Neoplasia 1 (MEN1) (Internal Region) antibodyMEN1 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Multiple Endocrine Neoplasia 1 (MEN1) (AA 1-615) antibodyMEN1 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Multiple Endocrine Neoplasia 1 (MEN1) (AA 506-615) antibodyMEN1 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Multiple Endocrine Neoplasia 1 (MEN1) (C-Term) antibodyMEN1 适用: 人, 小鼠 WB, ChIP-seq, ChIP 宿主: 兔 Polyclonal unconjugated
anti-Multiple Endocrine Neoplasia 1 (MEN1) (Internal Region) antibodyMEN1 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
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ELISA_Dilution: 1:10,000 - 1:50,000
Immunohistochemistry_Dilution: 1:500
Western_Blot_Dilution: 1 μg/mL
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说明
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Anti-MEN1 Antibody has been tested in Western Blot and Immunohistochemistry. Expect a band at ~67.5, 68kDa in western blot using appropriate tissues and lysates. Anti-Menin1 should only be used for overexpressing conditions in western blot. Positive control used: Human Colon in IHC.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
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Buffer: 0.002 M Sodium Phosphate, 0.15 M Sodium Chloride, pH 7.0
Stabilizer: None
Preservative: 0.01 % (w/v) Sodium Azide -
储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store vial at -20° C or below prior to opening. This vial contains a relatively low volume of reagent (25 μL). To minimize loss of volume dilute 1:10 by adding 225 μL of the buffer stated above directly to the vial. Recap, mix thoroughly and briefly centrifuge to collect the volume at the bottom of the vial. Use this intermediate dilution when calculating final dilutions as recommended below. Store the vial at -20°C or below after dilution. Avoid cycles of freezing and thawing.
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有效期
- 12 months
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- Menin (MEN1) (Multiple Endocrine Neoplasia 1 (MEN1))
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别名
- MEN1
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背景
- Chicken Anti-Menin1 Antibody, Menin 1, Menin, SCG2, Multiple Endocrine Neoplasia I, MEAI,Menin is a scaffold protein that functions in histone modification and epigenetic gene regulation. It is thought to regulate several pathways and processes by altering chromatin structure through the modification of histones. Essential component of a MLL/SET1 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3 (H3K4). Functions as a transcriptional regulator. Binds to the TERT promoter and represses telomerase expression. Plays a role in TGFB1-mediated inhibition of cell-proliferation, possibly regulating SMAD3 transcriptional activity. Represses JUND-mediated transcriptional activation on AP1 sites, as well as that mediated by NFKB subunit RELA. Positively regulates HOXC8 and HOXC6 gene expression. May be involved in normal hematopoiesis through the activation of HOXA9 expression. May be involved in DNA repair. Anti-MEN1 Antibody is useful for researchers interested in Multiple Endocrine Neoplasia Type I, Insulinoma, Cancer Research and Epigenetic Research.
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基因ID
- 4221
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NCBI登录号
- NP_000235
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UniProt
- O00255
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途径
- Chromatin Binding, Positive Regulation of Endopeptidase Activity
抗原
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