APP 抗体 (AA 483-699)
Quick Overview for APP 抗体 (AA 483-699) (ABIN7539850)
抗原
See all APP 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 483-699
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原理
- APP Antibody
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纯化方法
- Purified antibody
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免疫原
- Purified recombinant fragment of human APP (AA: 483-699) expressed in E. Coli.
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亚型
- IgG1
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应用备注
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ELISA: 1/10000
ICC: 1/200 - 1/1000
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限制
- 仅限研究用
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缓冲液
- Purified antibody in PBS with 0.05 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
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- APP (Amyloid beta (A4) Precursor Protein (APP))
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别名
- APP
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背景
- This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene.
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分子量
- 87 kDa
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基因ID
- 351
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UniProt
- P05067
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途径
- Caspase Cascade in Apoptosis, EGFR Signaling Pathway, Transition Metal Ion Homeostasis, Skeletal Muscle Fiber Development, Toll-Like Receptors Cascades, Feeding Behaviour
抗原
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