GAB2 抗体 (AA 332-476)
Quick Overview for GAB2 抗体 (AA 332-476) (ABIN7539834)
抗原
See all GAB2 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 332-476
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原理
- GAB2 Antibody
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纯化方法
- Purified antibody
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免疫原
- Purified recombinant fragment of human GAB2 (AA: 332-476) expressed in E. Coli.
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亚型
- IgG2a
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应用备注
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ELISA: 1/10000
FCM: 1/200 - 1/400
ICC: 1/200 - 1/1000
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限制
- 仅限研究用
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缓冲液
- Purified antibody in PBS with 0.05 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
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- GAB2 (GRB2-Associated Binding Protein 2 (GAB2))
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别名
- GAB2
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背景
- This gene is a member of the GRB2-associated binding protein (GAB) gene family. These proteins contain pleckstrin homology (PH) domain, and bind SHP2 tyrosine phosphatase and GRB2 adapter protein. They act as adapters for transmitting various signals in response to stimuli through cytokine and growth factor receptors, and T- and B-cell antigen receptors. The protein encoded by this gene is the principal activator of phosphatidylinositol-3 kinase in response to activation of the high affinity IgE receptor. Two alternatively spliced transcripts encoding different isoforms have been described for this gene.
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分子量
- 74.5 kDa
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基因ID
- 9846
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UniProt
- Q9UQC2
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途径
- TCR Signaling, Fc-epsilon Receptor Signaling Pathway, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, BCR Signaling, Warburg Effect
抗原
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