MCM3 抗体
Quick Overview for MCM3 抗体 (ABIN7539779)
抗原
See all MCM3 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
-
-
原理
- MCM3 Antibody
-
纯化方法
- Purified antibody
-
免疫原
- Purified recombinant fragment of human MCM3 expressed in E. Coli.
-
亚型
- IgG1
-
-
-
-
应用备注
-
FCM: 1/200 - 1/400
ICC: 1/50 - 1/200
-
限制
- 仅限研究用
-
-
-
缓冲液
- Purified antibody in PBS with 0.05 % sodium azide.
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- 4 °C,-20 °C
-
储存方法
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
-
-
- MCM3 (Minichromosome Maintenance Complex Component 3 (MCM3))
-
别名
- MCM3
-
背景
- The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein is a subunit of the protein complex that consists of MCM2-7. It has been shown to interact directly with MCM5/CDC46. This protein also interacts with and is acetylated by MCM3AP, a chromatin-associated acetyltransferase. The acetylation of this protein inhibits the initiation of DNA replication and cell cycle progression. Several transcript variants encoding different isoforms have been found for this gene.
-
分子量
- 91 kDa
-
基因ID
- 4172
-
UniProt
- P25205
-
途径
- DNA Damage Repair, Mitotic G1-G1/S Phases, DNA Replication, Chromatin Binding, Synthesis of DNA
抗原
-