CD36 抗体
Quick Overview for CD36 抗体 (ABIN7539626)
抗原
See all CD36 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- Purified Anti-Human CD36 Antibody[ 5-271]
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特异性
- Human
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纯化方法
- Protein A/G Purified
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免疫原
- Recombinant Human CD36 protein
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亚型
- IgG2a, kappa
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anti-CD36 (CD36) (Extracellular Domain) antibody
CD36 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-CD36 (CD36) (AA 99-114) antibodyCD36 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-CD36 (CD36) (C-Term) antibodyCD36 适用: 人 WB, IF, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
anti-CD36 (CD36) (N-Term) antibodyCD36 适用: 人, 小鼠, 大鼠, 犬, Pig, 兔, Cow, 山羊, 马, 豚鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-CD36 (CD36) (AA 213-242) antibodyCD36 适用: 人 FACS, WB, IHC, IF, ELISA 宿主: 兔 Polyclonal unconjugated
anti-CD36 (CD36) (AA 51-150) antibodyCD36 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-CD36 (CD36) antibody (FITC)CD36 适用: 人 FACS 宿主: 小鼠 Monoclonal CB38 FITC
anti-CD36 (CD36) (AA 30-130) antibodyCD36 适用: 人 IHC, ELISA 宿主: 小鼠 Monoclonal 5B6F5 unconjugated
anti-CD36 (CD36) (AA 30-130) antibodyCD36 适用: 人 FACS, ELISA 宿主: 小鼠 Monoclonal 5B6B2 unconjugated
anti-CD36 (CD36) (N-Term) antibodyCD36 适用: 人, 大鼠, 犬, Pig, 兔, Cow, 山羊, 马 WB, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
- FCM:2 μg/mL(1x10^5-5x10^5 cells)
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- ≥ 1 mg/mL
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缓冲液
- Phosphate buffered solution, pH 7.2, containing 0.05 % proclin 300.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles.
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- CD36
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别名
- CD36
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背景
- Multifunctional glycoprotein that acts as receptor for a broad range of ligands. Ligands can be of proteinaceous nature like thrombospondin, fibronectin, collagen or amyloid-beta as well as of lipidic nature such as oxidized low-density lipoprotein (oxLDL), anionic phospholipids, long-chain fatty acids and bacterial diacylated lipopeptides. They are generally multivalent and can therefore engage multiple receptors simultaneously, the resulting formation of CD36 clusters initiates signal transduction and internalization of receptor-ligand complexes. The dependency on coreceptor signaling is strongly ligand specific. Cellular responses to these ligands are involved in angiogenesis, inflammatory response, fatty acid metabolism, taste and dietary fat processing in the intestine (Probable). Binds long-chain fatty acids and facilitates their transport into cells, thus participating in muscle lipid utilization, adipose energy storage, and gut fat absorption (By similarity) (PubMed:18353783, PubMed:21610069). Mechanistically, binding of fatty acids activates downstream kinase LYN, which phosphorylates the palmitoyltransferase ZDHHC5 and inactivates it, resulting in the subsequent depalmitoylation of CD36 and caveolar endocytosis (PubMed:32958780). In the small intestine, plays a role in proximal absorption of dietary fatty acid and cholesterol for optimal chylomicron formation, possibly through the activation of MAPK1/3 (ERK1/2) signaling pathway (By similarity) (PubMed:18753675). Involved in oral fat perception and preferences (PubMed:22240721, PubMed:25822988). Detection into the tongue of long-chain fatty acids leads to a rapid and sustained rise in flux and protein content of pancreatobiliary secretions (By similarity). In taste receptor cells, mediates the induction of an increase in intracellular calcium levels by long-chain fatty acids, leading to the activation of the gustatory neurons in the nucleus of the solitary tract (By similarity). Important factor in both ventromedial hypothalamus neuronal sensing of long-chain fatty acid and the regulation of energy and glucose homeostasis (By similarity). Receptor for thrombospondins, THBS1 and THBS2, mediating their antiangiogenic effects (By similarity). Involved in inducing apoptosis in podocytes in response to elevated free fatty acids, acting together with THBS1 (By similarity). As a coreceptor for TLR4:TLR6 heterodimer, promotes inflammation in monocytes/macrophages. Upon ligand binding, such as oxLDL or amyloid-beta 42, interacts with the heterodimer TLR4:TLR6, the complex is internalized and triggers inflammatory response, leading to NF-kappa-B-dependent production of CXCL1, CXCL2 and CCL9 cytokines, via MYD88 signaling pathway, and CCL5 cytokine, via TICAM1 signaling pathway, as well as IL1B secretion, through the priming and activation of the NLRP3 inflammasome (By similarity) (PubMed:20037584). Selective and nonredundant sensor of microbial diacylated lipopeptide that signal via TLR2:TLR6 heterodimer, this cluster triggers signaling from the cell surface, leading to the NF-kappa-B-dependent production of TNF, via MYD88 signaling pathway and subsequently is targeted to the Golgi in a lipid-raft dependent pathway (By similarity) (PubMed:16880211).By Similarity8 Publications1 Publication (Microbial infection) Directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes and the internalization of particles independently of TLR signaling.
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UniProt
- P16671
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途径
- TLR signaling, Peptide Hormone Metabolism, Response to Growth Hormone Stimulus, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Regulation of Lipid Metabolism by PPARalpha, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Hepatitis C, Toll-Like Receptors Cascades, Lipid Metabolism, S100 Proteins
抗原
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