DKK1 抗体
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北京 101111
Quick Overview for DKK1 抗体 (ABIN7539243)
抗原
See all DKK1 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- Dkk-1 antibody
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纯化方法
- Protein-A purified
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免疫原
- recombinant human Dkk-1
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anti-Dickkopf Homolog 1 (DKK1) (AA 1-266) antibody
DKK1 适用: 人, 大鼠, 小鼠 WB, IHC (p), IF 宿主: 兔 Polyclonal RB52126 unconjugated
anti-Dickkopf Homolog 1 (DKK1) (AA 1-266) antibodyDKK1 适用: 人 WB, ELISA, IP, IHC (p) 宿主: 小鼠 Monoclonal 2A5 unconjugated
anti-Dickkopf Homolog 1 (DKK1) (AA 33-266) antibodyDKK1 适用: 人 WB 宿主: 小鼠 Monoclonal C5 unconjugated
anti-Dickkopf Homolog 1 (DKK1) (AA 81-180) antibodyDKK1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 4C10 unconjugated
anti-Dickkopf Homolog 1 (DKK1) (AA 201-266) antibodyDKK1 适用: 人, 犬 WB, ELISA, IHC (p), IF (p), IF (cc), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Dickkopf Homolog 1 (DKK1) (AA 36-260) antibodyDKK1 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Dickkopf Homolog 1 (DKK1) (AA 33-266) antibodyDKK1 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Dickkopf Homolog 1 (DKK1) (AA 33-266) antibodyDKK1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Dickkopf Homolog 1 (DKK1) (AA 71-266) antibodyDKK1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Dickkopf Homolog 1 (DKK1) (C-Term) antibodyVerified DKK1 适用: 人 WB, ELISA, IHC 宿主: 山羊 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Centrifuge vial prior to opening. Reconstitute in sterile water to a concentration of 0.1-1.0 mg/mL.
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缓冲液
- PBS
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储存条件
- 4 °C,-20 °C
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储存方法
- The lyophilized antibody is stable for at least 2 years at -20°C. After sterile reconstitution the antibody is stable at 2-8°C for up to 6 months. Frozen aliquots are stable for at least 6 months when stored at -20°C. Addition of a carrier protein or 50% glycerol is recommended for frozen aliquots.
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有效期
- 24 months
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- DKK1 (Dickkopf Homolog 1 (DKK1))
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别名
- Dkk-1
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背景
- Dickkopf-related protein-1, Dickkopf-1, SK,DKK-1 is a member of the DKK protein family which also includes DKK-2, DKK-3 and DKK-4. DKK-1 was originally identified as a Xenopus head forming molecule that behaves as an antagonist for Wnt signaling. Subsequent studies have shown that DKK-1 and DKK-4 play an important regulatory role in the Wnt /β-catenin signaling pathway by forming inhibitory complexes with LDL receptor-related proteins 5 and 6 (LRP5 and LRP6), which are essential components of the Wnt/βcatenin signaling system. LPR5 and LPR6 are single-pass transmembrane proteins that appear to act as co-receptors for Wnt ligands involved in the Wnt/βcatenin signaling cascade. It has been suggested that by inhibiting Wnt/β-catenin signaling, which is essential for posterior patterning in vertebrates, DKK-1 permits anterior development. This notion is supported by the finding that mice deficient of DKK-1 expression lack head formation and die during embryogenesis. Recombinant human DKK-1 fused to a C terminal His-tag derived from E. coli is a 26 kDa protein containing 235 amino-acid residues.
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基因ID
- 22943
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NCBI登录号
- NM_012242, NP_036374
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UniProt
- O94907
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途径
- WNT signaling, Regulation of Muscle Cell Differentiation, Positive Regulation of fat Cell Differentiation
抗原
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