DKK2 抗体
Quick Overview for DKK2 抗体 (ABIN7539241)
抗原
See all DKK2 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- Dkk-2 antibody
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纯化方法
- Protein-A purified
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免疫原
- recombinant human Dkk-2
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anti-Dickkopf 2 Homolog (DKK2) (AA 34-259) antibody
DKK2 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Dickkopf 2 Homolog (DKK2) (AA 124-173) antibodyDKK2 适用: 人, 小鼠, 大鼠, 犬, 豚鼠, 马, 兔, Bat, 猴, Pig WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Dickkopf 2 Homolog (DKK2) (AA 159-258) antibodyDKK2 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Dickkopf 2 Homolog (DKK2) (AA 38-258) antibodyDKK2 适用: 人 WB 宿主: 小鼠 Monoclonal C1 unconjugated
anti-Dickkopf 2 Homolog (DKK2) (C-Term) antibodyDKK2 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Dickkopf 2 Homolog (DKK2) (N-Term) antibodyDKK2 适用: 人 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
anti-Dickkopf 2 Homolog (DKK2) (AA 31-62), (N-Term) antibodyDKK2 适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Dickkopf 2 Homolog (DKK2) antibodyDKK2 适用: 人, 小鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Dickkopf 2 Homolog (DKK2) antibodyDKK2 适用: 人, 小鼠 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Dickkopf 2 Homolog (DKK2) antibodyDKK2 适用: 人, 小鼠 WB 宿主: 小鼠 Monoclonal 1833CT856-7-20 unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Centrifuge vial prior to opening. Reconstitute in sterile water to a concentration of 0.1-1.0 mg/mL.
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缓冲液
- PBS
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储存条件
- 4 °C,-20 °C
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储存方法
- The lyophilized antibody is stable for at least 2 years at -20°C. After sterile reconstitution the antibody is stable at 2-8°C for up to 6 months. Frozen aliquots are stable for at least 6 months when stored at -20°C. Addition of a carrier protein or 50% glycerol is recommended for frozen aliquots.
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有效期
- 24 months
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- DKK2 (Dickkopf 2 Homolog (DKK2))
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别名
- Dkk-2
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背景
- Dickkopf-related protein-2, Dickkopf-2,The dickkopf (DKK)-related protein family is comprised of four central members, DKK-1 - 4, along with the distantly-related DKK family member DKK-11 (Soggy), which is thought to be a descendent of an ancestral DKK-3 precursor due to its unique sequence homology to DKK-3 and no other DKK family member. DKK family members, with the exception of the divergent Soggy, share two conserved cysteine-rich domains and show very little sequence similarity outside of these domains. Playing an important regulatory role in vertebrate development through localized inhibition of Wnt-regulated processes, including anterior-posterior axial patterning, limb development, somitogenesis, and eye formation, DKKs have also been implicated post-developmentally in bone formation, bone disease, cancer, and neurodegenerative diseases. DKK proteins typically play an important regulatory role in the Wnt/β-catenin signaling pathway by forming inhibitory complexes with LDL receptor-related proteins 5 and 6 (LRP5 and LRP6), which are essential components of the Wnt/β-catenin signaling system. LRP5 and LRP6 are single-pass transmembrane proteins that appear to act as co-receptors for Wnt ligands involved in the Wnt/β-catenin signaling cascade. DKK-2 has been shown to both inhibit and enhance canonical Wnt signaling, enhancing Wnt signaling through direct high-affinity binding of DKK-2 to LRP6 during LRP6 overexpression, while inhibiting Wnt signaling and promoting LRP6 internalization through the formation of a ternary complex between DKK-2, LRP6, and Kremen-2. Recombinant Human DKK-2 fused to a C terminal His-tag derived from E. coli has a molecular weight of 26.0 kDa and contains 234 amino acid residues.
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基因ID
- 22943
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NCBI登录号
- NM_012242, NP_036374
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UniProt
- O94907
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途径
- WNT signaling
抗原
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