GZMA 抗体
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北京 101111
Quick Overview for GZMA 抗体 (ABIN7505978)
抗原
See all GZMA 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- Anti-Hu Granzyme A Purified
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特异性
- The mouse monoclonal CB9 recognizes granzyme A, a 28 kDa serine protease expressed intracellularly in activated Tc cells and NK cells.
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纯化方法
- Purified by protein-A affinity chromatography.
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免疫原
- Full length human granzyme A
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亚型
- IgG1 kappa
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应用备注
- Flow cytometry: Recommended dilution: 5-10 μg/mL, intracellular staining.
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限制
- 仅限研究用
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浓度
- 1 mg/mL
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缓冲液
- Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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储存方法
- Store at 2-8°C. Do not freeze.
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- GZMA (Granzyme A (Granzyme 1, Cytotoxic T-Lymphocyte-Associated serine Esterase 3) (GZMA))
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别名
- Granzyme A
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背景
- Granzyme A,Granzyme A is a serine protease expressed in the cytoplasmic granules of T cells and NK cells. Vectorial secretion of perforin and granzymes is responsible for their granule-mediated cytotoxicity. Similarly to granzyme B, granzyme A acts to destroy the target cells by proteolysis of their particular components. In case of granzyme A the targets are e.g. APEX1 (it destroys its oxidative repair activity), and nucleosome assembly protein SET (it disrupts its nucleosome assembly activity and allows the SET complex to translocate into the nucleus to nick and degrade the DNA).,HFSP, CTLA3, GrA
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基因ID
- 3001
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UniProt
- P12544
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途径
- Apoptosis
抗原
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