SIGLEC5 抗体 (Extracellular Domain) (APC)
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Quick Overview for SIGLEC5 抗体 (Extracellular Domain) (APC) (ABIN7505866)
抗原
See all SIGLEC5 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- Extracellular Domain
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原理
- Anti-Hu CD170 APC
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特异性
- The mouse monoclonal antibody 1A5 recognizes an extracellular epitope of CD170 (Siglec-5, sialic acid binding Ig-like lectin 5), a transmembrane glycoprotein expressed strongly by neutrophils, macrophages activated during infections, monocytes, and dendritic cells. As in case with other anti-CD170 antibodies, this antibody crossreacts with Siglec-14, whose first two Ig domains are almost identical to those of CD170.
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纯化方法
- Purified antibody is conjugated with activated allophycocyanin (APC) under optimum conditions and unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.
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免疫原
- Fusion protein composed of human CD170 extracellular domain and Fc region of human IgG1
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亚型
- IgG1
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anti-Sialic Acid Binding Ig-Like Lectin 5 (SIGLEC5) (AA 17-230) antibody
SIGLEC5 适用: 人 ELISA, FACS 宿主: 小鼠 Monoclonal 3F5A3 unconjugated
anti-Sialic Acid Binding Ig-Like Lectin 5 (SIGLEC5) antibodySIGLEC5 适用: 人, 小鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Sialic Acid Binding Ig-Like Lectin 5 (SIGLEC5) (AA 147-335) antibodySIGLEC5 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Sialic Acid Binding Ig-Like Lectin 5 (SIGLEC5) (N-Term) antibodySIGLEC5 适用: 人, 小鼠 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
anti-Sialic Acid Binding Ig-Like Lectin 5 (SIGLEC5) (AA 452-551) antibodySIGLEC5 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Sialic Acid Binding Ig-Like Lectin 5 (SIGLEC5) (AA 458-551) antibody (Biotin)SIGLEC5 适用: 人 WB 宿主: 兔 Polyclonal Biotin
anti-Sialic Acid Binding Ig-Like Lectin 5 (SIGLEC5) (Extracellular Domain) antibodySIGLEC5 适用: 人, Non-Human Primate ELISA, IP, ICC, FACS, IHC (fro) 宿主: 小鼠 Monoclonal 1A5 unconjugated
anti-Sialic Acid Binding Ig-Like Lectin 5 (SIGLEC5) (Extracellular Domain) antibody (PE)SIGLEC5 适用: 人, Non-Human Primate FACS 宿主: 小鼠 Monoclonal 1A5 PE
anti-Sialic Acid Binding Ig-Like Lectin 5 (SIGLEC5) (AA 18-135) antibodySIGLEC5 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Sialic Acid Binding Ig-Like Lectin 5 (SIGLEC5) (AA 458-551) antibodySIGLEC5 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
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应用备注
- Flow cytometry: The reagent is designed for analysis of human blood cells using 10 μL reagent / 100 μL of whole blood or 106 cells in a suspension. The content of a vial (1 ml) is sufficient for 100 tests.
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限制
- 仅限研究用
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缓冲液
- Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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储存方法
- Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
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- SIGLEC5 (Sialic Acid Binding Ig-Like Lectin 5 (SIGLEC5))
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别名
- CD170
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背景
- Sialic acid binding Ig like lectin 5,CD170, also known as Siglec 5 (sialic acid binding Ig-like lectin 5) is a type 1 transmembrane glycoprotein containing two cytoplasmic immunoreceptor tyrosine inhibitory motifs (ITIMs). CD170 forms homodimers and functions as an inhibitory receptor able to downregulate cell activation. It binds to alpha2,3- and alpha2,6-linked sialic acid ligands, e.g. on glycophorin A (CD235a). Aberrant expression of CD170 by CD34+ progenitor cells can be observed in case of acute myeloid leukemias.,OBBP2, OB-BP2, SIGLEC-5, SIGLEC5
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基因ID
- 8778
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UniProt
- O15389
抗原
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