RUVBL1 抗体
Quick Overview for RUVBL1 抗体 (ABIN7469584)
抗原
See all RUVBL1 抗体适用
宿主
克隆类型
标记
应用范围
质量等级
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交叉反应
- 人
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纯化方法
- Purified by antigen-affinity chromatography.
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免疫原
- Recombinant protein encompassing a sequence within the center region of human RUVBL1. The exact sequence is proprietary.
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亚型
- IgG
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anti-RuvB-Like 1 (E. Coli) (RUVBL1) (AA 1-456) antibody
RUVBL1 适用: 人 WB, ELISA, IF, PLA 宿主: 小鼠 Monoclonal 3G4-1F8 unconjugated
anti-RuvB-Like 1 (E. Coli) (RUVBL1) (AA 1-240) antibodyRUVBL1 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-RuvB-Like 1 (E. Coli) (RUVBL1) (AA 101-400) antibodyRUVBL1 适用: 人 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-RuvB-Like 1 (E. Coli) (RUVBL1) antibodyRUVBL1 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-RuvB-Like 1 (E. Coli) (RUVBL1) antibodyRUVBL1 适用: 人 WB, IHC 宿主: 兔 Monoclonal unconjugated
anti-RuvB-Like 1 (E. Coli) (RUVBL1) antibodyRUVBL1 适用: 人 WB, FACS, ICC, DB 宿主: 小鼠 Monoclonal 2943C1a unconjugated
anti-RuvB-Like 1 (E. Coli) (RUVBL1) antibodyRUVBL1 适用: 人 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB23096 unconjugated
anti-RuvB-Like 1 (E. Coli) (RUVBL1) (N-Term) antibodyRUVBL1 适用: 人, 小鼠, 大鼠, Cow, 犬, 豚鼠, 马, 兔, 斑马鱼, 山羊 WB 宿主: 兔 Polyclonal unconjugated
anti-RuvB-Like 1 (E. Coli) (RUVBL1) (AA 1-214) antibodyRUVBL1 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-RuvB-Like 1 (E. Coli) (RUVBL1) (AA 247-280) antibodyRUVBL1 适用: 人 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB8415 unconjugated
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应用备注
- WB: 1:500-1:3000. IP: 1:100-1:500. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.
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说明
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Positive Control: A549 , H1299 , HCT116 , MCF-7 , 293T Validation: KO/KD
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.64 mg/mL
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缓冲液
- 0.1M Tris-Glycine ( pH 7), 20 % Glycerol, 0.01 % Thimerosal
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储存液
- Thimerosal (Merthiolate)
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注意事项
- This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
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- RUVBL1 (RuvB-Like 1 (E. Coli) (RUVBL1))
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别名
- RUVBL1
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背景
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Synonyms: RuvB like AAA ATPase 1 , ECP-54 , ECP54 , INO80H , NMP 238 , NMP238 , PONTIN , Pontin52 , RVB1 , TIH1 , TIP49 , TIP49A
Background: Possesses single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (3' to 5') activity. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. RUVBL1 plays an essential role in oncogenic transformation by MYC and also modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex. May be able to bind plasminogen at cell surface and enhance plasminogen activation. Essential for cell proliferation.
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分子量
- 50 kDa
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基因ID
- 8607
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UniProt
- Q9Y265
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途径
- Telomere Maintenance
抗原
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