MCTS1 抗体
Quick Overview for MCTS1 抗体 (ABIN7468574)
抗原
See all MCTS1 抗体适用
宿主
克隆类型
标记
应用范围
质量等级
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交叉反应
- 人, 小鼠, 大鼠
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纯化方法
- Purified by antigen-affinity chromatography.
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免疫原
- Recombinant protein encompassing a sequence within the center region of human MCTS1. The exact sequence is proprietary.
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亚型
- IgG
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anti-Malignant T Cell Amplified Sequence 1 (MCTS1) (AA 1-181) antibody
MCTS1 适用: 人 WB, IHC, IHC (p) 宿主: 小鼠 Monoclonal 2G2 unconjugated
anti-Malignant T Cell Amplified Sequence 1 (MCTS1) (AA 1-181) antibodyMCTS1 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Malignant T Cell Amplified Sequence 1 (MCTS1) antibodyMCTS1 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Malignant T Cell Amplified Sequence 1 (MCTS1) (AA 1-181) antibodyMCTS1 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Malignant T Cell Amplified Sequence 1 (MCTS1) (N-Term) antibodyVerified MCTS1 适用: 人 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Malignant T Cell Amplified Sequence 1 (MCTS1) (AA 1-181) antibodyMCTS1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1G1-2A2 unconjugated
anti-Malignant T Cell Amplified Sequence 1 (MCTS1) (N-Term) antibodyMCTS1 适用: 人, 大鼠, Cow, 犬, 豚鼠, 斑马鱼, 猴, Pig WB 宿主: 兔 Polyclonal unconjugated
anti-Malignant T Cell Amplified Sequence 1 (MCTS1) (AA 1-30), (N-Term) antibodyMCTS1 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal RB20015 unconjugated
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应用备注
- WB: 1:500-1:3000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.
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说明
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Positive Control: Jurkat , MDA-MB-231 Validation: KO/KD, Orthogonal, Overexpression
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- 1XPBS ( pH 7), 1 % BSA, 20 % Glycerol, 0.01 % Thimerosal
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储存液
- Thimerosal (Merthiolate)
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注意事项
- This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
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- MCTS1 (Malignant T Cell Amplified Sequence 1 (MCTS1))
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别名
- MCTS1 re-initiation and release factor
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背景
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Synonyms: MCTS1 re-initiation and release factor , MCT-1 , MCT1
Background: Anti-oncogene that play a role in cell cycle regulation, decreases cell doubling time and anchorage-dependent growth, shortens the duration of G1 transit time and G1/S transition. When constituvely expressed, increases CDK4 and CDK6 kinases activity and CCND1/cyclin D1 protein level, as well as G1 cyclin/CDK complex formation. Plays a role as translation enhancer, Recruits the density-regulated protein/DENR and binds to the cap complex of the 5'-terminus of mRNAs, subsequently altering the mRNA translation profile, Up-regulates protein levels of BCL2L2, TFDP1, MRE11A, CCND1 and E2F1, while mRNA levels remains constant. Hyperactivates DNA damage signaling pathway, increased gamma-irradiation-induced phosphorylation of histone H2AX, and induces damage foci formation. Increases the overall number of chromosomal abnormalities such as larger chromosomes formation and multiples chromosomal fusions when over-expressed in gamma-irradiated cells. May play a role in promoting lymphoid tumor development: lymphoid cell lines over-expressing MCTS1 exhibit increased growth rates and display increased protection against apoptosis. May contribute to the pathogenesis and progression of breast cancer via promotion of angiogenesis through the decline of inhibitory THBS1/thrombospondin-1, and inhibition of apoptosis. Involved in the process of proteosome degradation to down-regulate Tumor suppressor p53/TP53 in breast cancer cell, Positively regulates phosphorylation of MAPK1 and MAPK3.
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分子量
- 21 kDa
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基因ID
- 28985
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UniProt
- Q9ULC4
抗原
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