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- 抗原 See all MCTS1 抗体
- MCTS1 (Malignant T Cell Amplified Sequence 1 (MCTS1))
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抗原表位
- AA 1-181
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This MCTS1 antibody is un-conjugated
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应用范围
- ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)
- 交叉反应
- 人
- 纯化方法
- >95%, Protein G purified
- 免疫原
- Recombinant Human Malignant T-cell-amplified sequence 1 protein (1-181AA)
- 亚型
- IgG
- Top Product
- Discover our top product MCTS1 Primary Antibody
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anti-Malignant T Cell Amplified Sequence 1 (MCTS1) (AA 1-181) antibody
MCTS1 适用: 人 WB, IHC, IHC (p) 宿主: 小鼠 Monoclonal 2G2 unconjugated
anti-Malignant T Cell Amplified Sequence 1 (MCTS1) (AA 1-181) antibodyMCTS1 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Malignant T Cell Amplified Sequence 1 (MCTS1) antibodyMCTS1 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Malignant T Cell Amplified Sequence 1 (MCTS1) antibodyMCTS1 适用: 人, 小鼠, 大鼠 IF 宿主: 兔 Polyclonal unconjugated
anti-Malignant T Cell Amplified Sequence 1 (MCTS1) (C-Term) antibodyMCTS1 适用: 人, 小鼠, 大鼠, 犬, Cow, Pig, 小鸡 IF (p), IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Malignant T Cell Amplified Sequence 1 (MCTS1) antibodyMCTS1 适用: 小鼠, 大鼠 WB, ICC 宿主: 兔 Polyclonal unconjugated
anti-Malignant T Cell Amplified Sequence 1 (MCTS1) (AA 251-350) antibodyMCTS1 适用: 人 WB, ELISA, FACS, IF (p), IF (cc), IHC (p), IHC (fro), ICC 宿主: 兔 Polyclonal unconjugated
anti-Malignant T Cell Amplified Sequence 1 (MCTS1) (AA 251-350) antibody (Alexa Fluor 647)MCTS1 适用: 人 WB, FACS, IF (p), IF (cc) 宿主: 兔 Polyclonal Alexa Fluor 647
anti-Malignant T Cell Amplified Sequence 1 (MCTS1) (N-Term) antibodyMCTS1 适用: 人, 大鼠, 犬, Cow, Pig, 豚鼠, 斑马鱼, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Malignant T Cell Amplified Sequence 1 (MCTS1) (AA 1-181) antibodyMCTS1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1G1-2A2 unconjugated
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- 应用备注
- Recommended dilution: IHC:1:20-1:200, IF:1:200-1:500,
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4 - 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C,-80 °C
- 储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- 抗原
- MCTS1 (Malignant T Cell Amplified Sequence 1 (MCTS1))
- 别名
- MCTS1 (MCTS1 产品)
- 别名
- MCT-1 antibody, MCT1 antibody, MCT1a antibody, cb517 antibody, zgc:55682 antibody, 1500019M23Rik antibody, zgc:56242 antibody, mcts1 antibody, MGC89874 antibody, MCTS1 antibody, MCT-1A antibody, mct-1 antibody, mct1 antibody, MCT-1B antibody, mcts1-a antibody, mcts1-b antibody, MCTS1, re-initiation and release factor antibody, solute carrier family 16 (monocarboxylate transporter), member 1b antibody, malignant T cell amplified sequence 1 antibody, malignant T-cell amplified sequence 1 antibody, solute carrier family 16 member 1 antibody, malignant T-cell amplified sequence 1 S homeolog antibody, monocarboxylate transporter 1 antibody, malignant T-cell amplified sequence 1 L homeolog antibody, MCTS1 antibody, slc16a1b antibody, Mcts1 antibody, mcts1 antibody, SLC16A1 antibody, mcts1.S antibody, MCT1 antibody, mcts1.L antibody
- 背景
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Background: Anti-oncogene that play a role in cell cycle regulation, decreases cell doubling time and anchorage-dependent growth, shortens the duration of G1 transit time and G1/S transition. When constituvely expressed, increases CDK4 and CDK6 kinases activity and CCND1/cyclin D1 protein level, as well as G1 cyclin/CDK complex formation. Involved in translation initiation, promotes recruitment of aminoacetyled initiator tRNA to P site of 40S ribosomes. Can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits. Plays a role as translation enhancer, recruits the density-regulated protein/DENR and binds to the cap complex of the 5\'-terminus of mRNAs, subsequently altering the mRNA translation profile, up-regulates protein levels of BCL2L2, TFDP1, MRE11A, CCND1 and E2F1, while mRNA levels remains constant. Hyperactivates DNA damage signaling pathway, increased gamma-irradiation-induced phosphorylation of histone H2AX, and induces damage foci formation. Increases the overall number of chromosomal abnormalities such as larger chromosomes formation and multiples chromosomal fusions when overexpressed in gamma-irradiated cells. May play a role in promoting lymphoid tumor development: lymphoid cell lines overexpressing MCTS1 exhibit increased growth rates and display increased protection against apoptosis. May contribute to the pathogenesis and progression of breast cancer via promotion of angiogenesis through the decline of inhibitory THBS1/thrombospondin-1, and inhibition of apoptosis. Involved in the process of proteasome degradation to down-regulate Tumor suppressor p53/TP53 in breast cancer cell, Positively regulates phosphorylation of MAPK1 and MAPK3. Involved in translation initiation, promotes aminoacetyled initiator tRNA to P site of 40S ribosomes. Can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits.
Aliases: FLJ39637 antibody, Malignant T cell amplified sequence 1 antibody, Malignant T cell-amplified sequence 1 antibody, MCT 1 antibody, MCT-1 antibody, MCT1 antibody, MCTS 1 antibody, MCTS1 antibody, MCTS1_HUMAN antibody, Multiple copies T cell malignancies 1 antibody, Multiple copies T cell malignancies antibody, Multiple copies T-cell malignancies antibody, Oncogene MCT 1 antibody, Oncogene MCT1 antibody
- UniProt
- Q9ULC4
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