Double-Strand Break Repair Protein MRE11 (MRE11) (AA 182-582) 抗体
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北京 101111
Quick Overview for Double-Strand Break Repair Protein MRE11 (MRE11) (AA 182-582) 抗体 (ABIN7468277)
抗原
适用
宿主
克隆类型
标记
应用范围
质量等级
克隆位点
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抗原表位
- AA 182-582
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交叉反应
- 人, 大鼠
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纯化方法
- Protein G purified
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免疫原
- Amino acids 182-582 of Mre11 expressed in E. coli.
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亚型
- IgG1
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应用备注
- WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.
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说明
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Positive Control: HeLa , Jurkat , Raji , NCI-H929 , 293T , human Mre11-transfected 293T , PC-12 Validation: Comparison, KO/KD, Orthogonal
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.45 mg/mL
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缓冲液
- PBS, No Preservative
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储存液
- Without preservative
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储存条件
- 4 °C,-20 °C
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储存方法
- Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
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- Double-Strand Break Repair Protein MRE11 (MRE11)
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别名
- MRE11 homolog, double strand break repair nuclease
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背景
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Synonyms: MRE11 homolog, double strand break repair nuclease , ATLD , HNGS1 , MRE11A , MRE11B
Background: This gene encodes a nuclear protein involved in homologous recombination, telomere length maintenance, and DNA double-strand break repair. By itself, the protein has 3' to 5' exonuclease activity and endonuclease activity. The protein forms a complex with the RAD50 homolog, this complex is required for nonhomologous joining of DNA ends and possesses increased single-stranded DNA endonuclease and 3' to 5' exonuclease activities. In conjunction with a DNA ligase, this protein promotes the joining of noncomplementary ends in vitro using short homologies near the ends of the DNA fragments. This gene has a pseudogene on chromosome 3. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
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分子量
- 81 kDa
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基因ID
- 4361
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UniProt
- P49959
抗原
-
