Double-Strand Break Repair Protein MRE11 (MRE11) 抗体
Our Local Distributor
北京 101111
Quick Overview for Double-Strand Break Repair Protein MRE11 (MRE11) 抗体 (ABIN7468276)
抗原
适用
宿主
克隆类型
标记
应用范围
-
-
交叉反应
- 人, 小鼠, 大鼠
-
纯化方法
- Purified by antigen-affinity chromatography.
-
免疫原
- Recombinant protein encompassing a sequence within the center region of human Mre11. The exact sequence is proprietary.
-
亚型
- IgG
-
-
-
-
应用备注
- WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. IP: 1:100-1:500. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.
-
说明
-
Positive Control: A431 , C8D30 , NIH-3T3 , PC-12 , HeLa , MRE11A-transfected 293T Validation: KO/KD, Orthogonal, Overexpression
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
浓度
- 0.9 mg/mL
-
缓冲液
- 1XPBS pH 7, 20 % Glycerol, 0.025 % ProClin 300
-
储存液
- ProClin
-
注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- 4 °C,-20 °C
-
储存方法
- Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
-
-
- Double-Strand Break Repair Protein MRE11 (MRE11)
-
别名
- MRE11 homolog, double strand break repair nuclease
-
背景
-
Synonyms: MRE11 homolog, double strand break repair nuclease , ATLD , HNGS1 , MRE11A , MRE11B
Background: This gene encodes a nuclear protein involved in homologous recombination, telomere length maintenance, and DNA double-strand break repair. By itself, the protein has 3' to 5' exonuclease activity and endonuclease activity. The protein forms a complex with the RAD50 homolog, this complex is required for nonhomologous joining of DNA ends and possesses increased single-stranded DNA endonuclease and 3' to 5' exonuclease activities. In conjunction with a DNA ligase, this protein promotes the joining of noncomplementary ends in vitro using short homologies near the ends of the DNA fragments. This gene has a pseudogene on chromosome 3. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq]
-
分子量
- 81 kDa
-
基因ID
- 4361
-
UniProt
- P49959
抗原
-
