ARID1A 抗体 (C-Term)
Quick Overview for ARID1A 抗体 (C-Term) (ABIN7467969)
抗原
See all ARID1A 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- C-Term
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交叉反应
- 人, 小鼠
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纯化方法
- Affinity purified by Protein G.
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免疫原
- Recombinant protein encompassing a sequence within the C-terminus region of human ARID1A. The exact sequence is proprietary.
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亚型
- IgG1
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应用备注
- WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.
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说明
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Positive Control: 293T
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 2.61 mg/mL
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缓冲液
- PBS, No Preservative
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储存液
- Without preservative
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储存条件
- 4 °C,-20 °C
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储存方法
- Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
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- ARID1A (AT Rich Interactive Domain 1A (SWI-Like) (ARID1A))
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别名
- AT-rich interaction domain 1A
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背景
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Synonyms: AT-rich interaction domain 1A , B120 , BAF250 , BAF250a , BM029 , C1orf4 , CSS2 , ELD , MRD14 , OSA1 , P270 , SMARCF1 , hELD , hOSA1
Background: This gene encodes a member of the SWI/SNF family, whose members have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. It possesses at least two conserved domains that could be important for its function. First, it has a DNA-binding domain that can specifically bind an AT-rich DNA sequence known to be recognized by a SNF/SWI complex at the beta-globin locus. Second, the C-terminus of the protein can stimulate glucocorticoid receptor-dependent transcriptional activation. It is thought that the protein encoded by this gene confers specificity to the SNF/SWI complex and may recruit the complex to its targets through either protein-DNA or protein-protein interactions. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]
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分子量
- 242 kDa
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基因ID
- 8289
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UniProt
- O14497
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途径
- Intracellular Steroid Hormone Receptor Signaling Pathway, Tube Formation
抗原
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