BRISC and BRCA1 A Complex Member 1 (BABAM1) (N-Term) 抗体
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Quick Overview for BRISC and BRCA1 A Complex Member 1 (BABAM1) (N-Term) 抗体 (ABIN7467205)
抗原
See all BRISC and BRCA1 A Complex Member 1 (BABAM1) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- N-Term
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交叉反应
- 人
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纯化方法
- Affinity purified by Protein G.
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免疫原
- Recombinant protein encompassing a sequence within the N-terminus region of human HSPC142. The exact sequence is proprietary.
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亚型
- IgG2a
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anti-BRISC and BRCA1 A Complex Member 1 (BABAM1) (AA 36-85) antibody
BABAM1 适用: 人, 小鼠, 犬, 豚鼠, 马, 猴 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-BRISC and BRCA1 A Complex Member 1 (BABAM1) (AA 1-329) antibodyBABAM1 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-BRISC and BRCA1 A Complex Member 1 (BABAM1) (AA 116-143) antibodyBABAM1 适用: 人 WB, IHC (p), FACS 宿主: 兔 Polyclonal RB20468 unconjugated
anti-BRISC and BRCA1 A Complex Member 1 (BABAM1) (AA 9-37), (N-Term) antibodyBABAM1 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB20467 unconjugated
anti-BRISC and BRCA1 A Complex Member 1 (BABAM1) (N-Term) antibodyBABAM1 适用: 人, 小鼠, 犬, 豚鼠, 马, 大鼠, Cow WB 宿主: 兔 Polyclonal unconjugated
anti-BRISC and BRCA1 A Complex Member 1 (BABAM1) (Middle Region) antibodyBABAM1 适用: 人 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.
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说明
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Validation: Overexpression
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- PBS, No Preservative
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储存液
- Without preservative
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储存条件
- 4 °C,-20 °C
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储存方法
- Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
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- BRISC and BRCA1 A Complex Member 1 (BABAM1)
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别名
- BRISC and BRCA1 A complex member 1
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背景
- BRISC and BRCA1 A complex member 1 , C19orf62 , HSPC142 , MERIT40 , NBA1,Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it is required for the complex integrity and its localization at DSBs. Probably also plays a role as a component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin. In these 2 complexes, it is probably required to maintain the stability of BRE/BRCC45 and help the 'Lys-63'-linked deubiquitinase activity mediated by BRCC3/BRCC36. component.
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分子量
- 37 kDa
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基因ID
- 29086
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UniProt
- Q9NWV8
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途径
- Positive Regulation of Response to DNA Damage Stimulus
抗原
-
