CRTC1 抗体 (N-Term)
Quick Overview for CRTC1 抗体 (N-Term) (ABIN7466212)
抗原
See all CRTC1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- N-Term
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交叉反应
- 人
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纯化方法
- Purified by antigen-affinity chromatography.
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免疫原
- Recombinant protein encompassing a sequence within the N-terminus region of human TORC1. The exact sequence is proprietary.
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亚型
- IgG
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应用备注
- WB: 1:5000-1:20000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.
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说明
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Positive Control: human CRTC1-transfected 293T
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.9 mg/mL
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缓冲液
- 1XPBS ( pH 7), 20 % Glycerol, 0.025 % ProClin 300
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
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- CRTC1 (CREB Regulated Transcription Coactivator 1 (CRTC1))
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别名
- CREB regulated transcription coactivator 1
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背景
- CREB regulated transcription coactivator 1 , MAML2 , MECT1 , Mam-2 , TORC-1 , TORC1 , WAMTP1,Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PGC1alpha and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). In the hippocampus, involved in late-phase long-term potentiation (L-LTP) maintenance at the Schaffer collateral-CA1 synapses.
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分子量
- 67 kDa
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基因ID
- 23373
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UniProt
- Q6UUV9
抗原
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