NCOA2 抗体 (C-Term)
Quick Overview for NCOA2 抗体 (C-Term) (ABIN7465996)
抗原
See all NCOA2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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交叉反应
- 人
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纯化方法
- Purified by antigen-affinity chromatography.
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免疫原
- Recombinant protein encompassing a sequence within the C-terminus region of human NCOA2. The exact sequence is proprietary.
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亚型
- IgG
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anti-Nuclear Receptor Coactivator 2 (NCOA2) (AA 550-820) antibody
NCOA2 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Nuclear Receptor Coactivator 2 (NCOA2) (N-Term) antibodyNCOA2 适用: 人, 小鼠, 大鼠, 犬, 兔, Cow, 豚鼠, 马, Pig WB 宿主: 兔 Polyclonal unconjugated
anti-Nuclear Receptor Coactivator 2 (NCOA2) (AA 706-739) antibodyNCOA2 适用: 人 WB 宿主: 兔 Polyclonal RB54073 unconjugated
anti-Nuclear Receptor Coactivator 2 (NCOA2) (AA 1169-1203), (C-Term) antibodyNCOA2 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal RB50717 unconjugated
anti-Nuclear Receptor Coactivator 2 (NCOA2) (AA 1431-1462) antibodyNCOA2 适用: 人 WB 宿主: 兔 Polyclonal RB53913 unconjugated
anti-Nuclear Receptor Coactivator 2 (NCOA2) (C-Term) antibodyNCOA2 适用: 人, 小鼠 WB, IHC, IP, IHC (p), IF, PLA 宿主: 兔 Polyclonal unconjugated
anti-Nuclear Receptor Coactivator 2 (NCOA2) (N-Term) antibodyNCOA2 适用: 人, 小鼠, 大鼠, 犬, 兔, 马, Pig, Bat, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Nuclear Receptor Coactivator 2 (NCOA2) (AA 702-751), (pSer736) antibodyNCOA2 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.
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说明
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Positive Control: HeLa nucleus
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- 1XPBS ( pH 7), 1 % BSA, 20 % Glycerol, 0.01 % Thimerosal
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储存液
- Thimerosal (Merthiolate)
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注意事项
- This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
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- NCOA2 (Nuclear Receptor Coactivator 2 (NCOA2))
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别名
- nuclear receptor coactivator 2
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背景
- Nuclear receptor coactivator 2 , GRIP1 , KAT13C , NCoA-2 , SRC2 , TIF2 , bHLHe75,The NCOA2 gene encodes nuclear receptor coactivator 2, which aids in the function of nuclear hormone receptors. Nuclear hormone receptors are conditional transcription factors that play important roles in various aspects of cell growth, development, and homeostasis by controlling expression of specific genes. Members of the nuclear hormone receptor superfamily, which includes the 5 steroid receptors and class II nuclear receptors (see below), are structurally characterized by 3 distinct domains: an N-terminal transcriptional activation domain, a central DNA-binding domain, and a C-terminal hormone-binding domain. Before the binding of hormone, steroid receptors, which are sometimes called class I of the nuclear hormone receptor family, remain inactive in a complex with heat-shock protein-90 (MIM 140571) and other stress family proteins. Binding of hormone induces critical conformational changes in steroid receptors that cause them to dissociate from the inhibitory complex, bind as homodimers to specific DNA enhancer elements associated with target genes, and modulate that gene's transcription. After binding to enhancer elements, transcription factors require transcriptional coactivator proteins to mediate their stimulation of transcription initiation (Hong et al., 1997 [PubMed 9111344]).[supplied by OMIM]
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分子量
- 159 kDa
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基因ID
- 10499
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UniProt
- Q15596
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途径
- Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Nuclear Hormone Receptor Binding, Regulation of Lipid Metabolism by PPARalpha, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, CXCR4-mediated Signaling Events, Thromboxane A2 Receptor Signaling
抗原
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