TLR3 抗体
Quick Overview for TLR3 抗体 (ABIN7465652)
抗原
See all TLR3 抗体适用
宿主
克隆类型
标记
应用范围
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交叉反应
 - 人, 小鼠, 大鼠
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纯化方法
 - Purified by antigen-affinity chromatography.
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免疫原
 - Recombinant protein encompassing a sequence within the center region of human TLR3. The exact sequence is proprietary.
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亚型
 - IgG
 
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应用备注
 - WB: 1:1000-1:10000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.
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说明
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Validation: Comparison
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限制
 - 仅限研究用
 
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状态
 - Liquid
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浓度
 - 1.4 mg/mL
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缓冲液
 - 1XPBS ( pH 7), 20 % Glycerol, 0.025 % ProClin 300
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储存液
 - ProClin
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注意事项
 - This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
 - 4 °C,-20 °C
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储存方法
 - Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
 
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- TLR3 (Toll-Like Receptor 3 (TLR3))
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别名
 - toll like receptor 3
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背景
 - Toll like receptor 3 , CD283 , IIAE2,The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor is most abundantly expressed in placenta and pancreas, and is restricted to the dendritic subpopulation of the leukocytes. It recognizes dsRNA associated with viral infection, and induces the activation of NF-kappaB and the production of type I interferons. It may thus play a role in host defense against viruses. Use of alternative polyadenylation sites to generate different length transcripts has been noted for this gene. [provided by RefSeq]
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分子量
 - 104 kDa
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基因ID
 - 7098
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UniProt
 - O15455
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途径
 - TLR signaling, Activation of Innate immune Response, Hepatitis C, Toll-Like Receptors Cascades
 
抗原
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