CTNNB1 抗体 (pSer675)
Quick Overview for CTNNB1 抗体 (pSer675) (ABIN7464470)
抗原
See all CTNNB1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
 - pSer675
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交叉反应
 - 人, 小鼠, 大鼠
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纯化方法
 - Purified by antigen-affinity chromatography.
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免疫原
 - Carrier-protein conjugated synthetic peptide surrounding phospho Ser675 of human beta Catenin. The exact sequence is proprietary.
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亚型
 - IgG
 
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应用备注
 - WB: 1:500-1:3000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.
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说明
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Positive Control: HeLa , Neuro2A , C8D30 , NIH-3T3 , C2C12 , PC-12 , Rat2
Validation: Orthogonal
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限制
 - 仅限研究用
 
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状态
 - Liquid
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浓度
 - 0.64 mg/mL
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缓冲液
 - 1XPBS ( pH 7), 1 % BSA, 20 % Glycerol, 0.025 % ProClin 300
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储存液
 - ProClin
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注意事项
 - This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
 - 4 °C,-20 °C
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储存方法
 - Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
 
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- CTNNB1 (Catenin (Cadherin-Associated Protein), beta 1, 88kDa (CTNNB1))
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别名
 - catenin beta 1
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背景
 - Catenin beta 1 , CTNNB , EVR7 , MRD19 , armadillo,Beta-catenin is an adherens junction protein. Adherens junctions (AJs, also called the zonula adherens) are critical for the establishment and maintenance of epithelial layers, such as those lining organ surfaces. AJs mediate adhesion between cells, communicate a signal that neighboring cells are present, and anchor the actin cytoskeleton. In serving these roles, AJs regulate normal cell growth and behavior. At several stages of embryogenesis, wound healing, and tumor cell metastasis, cells form and leave epithelia. This process, which involves the disruption and reestablishment of epithelial cell-cell contacts, may be regulated by the disassembly and assembly of AJs. AJs may also function in the transmission of the 'contact inhibition' signal, which instructs cells to stop dividing once an epithelial sheet is complete.[supplied by OMIM]
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分子量
 - 85 kDa
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基因ID
 - 1499
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UniProt
 - P35222
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途径
 - WNT signaling, Intracellular Steroid Hormone Receptor Signaling Pathway, Peptide Hormone Metabolism, Regulation of Muscle Cell Differentiation, Cell-Cell Junction Organization, Tube Formation, Maintenance of Protein Location, Signaling Events mediated by VEGFR1 and VEGFR2
 
抗原
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