BTLA 抗体
Quick Overview for BTLA 抗体 (ABIN7457868)
抗原
See all BTLA 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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纯化方法
- Purified
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过滤
- 0.2 μm filtered
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内毒素水平
- Low Endotoxin: Endotoxin level is < 2 EU/mg as Determined by LAL gel clotting assay.
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亚型
- IgG1, kappa
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anti-B and T Lymphocyte Associated (BTLA) antibody
BTLA 适用: 人 WB, FACS 宿主: 小鼠 Monoclonal 2E4 unconjugated
anti-B and T Lymphocyte Associated (BTLA) (AA 30-183) antibodyBTLA 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-B and T Lymphocyte Associated (BTLA) (AA 31-157) antibodyBTLA 适用: 人 ELISA, ICC 宿主: 小鼠 Monoclonal 7B8B4 unconjugated
anti-B and T Lymphocyte Associated (BTLA) (AA 31-157) antibodyBTLA 适用: 人 FACS, ELISA 宿主: 小鼠 Monoclonal 5G1G10 unconjugated
anti-B and T Lymphocyte Associated (BTLA) (AA 179-289) antibodyBTLA 适用: 人 FACS, ELISA 宿主: 小鼠 Monoclonal 4B12A7 unconjugated
anti-B and T Lymphocyte Associated (BTLA) (AA 221-289) antibodyBTLA 适用: 人, 小鼠 WB, FACS, ELISA, ICC, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-B and T Lymphocyte Associated (BTLA) antibodyBTLA 适用: 人 WB, IHC, IF, IHC (p) 宿主: 小鼠 Monoclonal 4D6 unconjugated
anti-B and T Lymphocyte Associated (BTLA) antibodyBTLA 适用: 人 WB, FACS, IF 宿主: 小鼠 Monoclonal 2G2 unconjugated
anti-B and T Lymphocyte Associated (BTLA) (AA 101-150) antibodyBTLA 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-B and T Lymphocyte Associated (BTLA) (AA 30-183) antibodyBTLA 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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说明
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Matching Isotype Control: AF/LE Purified Rat IgG1, κ Isotype Control (ABIN7469818)
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限制
- 仅限研究用
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浓度
- 0.5 mg/mL
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缓冲液
- PBS, pH 7.2. Azide Free (AF)/Low Endotoxin (LE)
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储存液
- Azide free
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储存条件
- 4 °C
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储存方法
- Store at 2~8°C. Do not freeze.
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- BTLA (B and T Lymphocyte Associated (BTLA))
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别名
- CD272
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背景
- B- and T-lymphocyte attenuator,Btla,B- and T-lymphocyte-associated protein,CD272,Btla,CD272, also known as B and T lymphocyte attenuator (BTLA), is an Ig superfamily co-inhitory receptor with structural similarity to programmed cell death 1 (PD-1) and CTLA-4. BTLA is expressed on B cells, T cells, macrophages, dendritic cells, NKT cells, and NK cells. Engagement of BTLA by its ligand herpes virus entry mediator (HVEM) is critical for negatively regulating immune response. The absence of BTLA with HVEM inhibitory interactions leads to increased experimental autoimmune encephalomyelitis severity, enhanced rejection of partially mismatched allografts, an increased CD8+ memory T cell population, increased severity of colitis, and reduced effectiveness of T regulatory cells. BTLA plays an important role in the induction of peripheral tolerance of both CD4+ and CD8+ T cells in vivo. Tolerant T cells have significantly higher expression of BTLA compared with effectors and naive T cells. BTLA may cooperate with CTLA-4 and PD-1 to control T cell tolerance and autoimmunity. It was reported that BTLA may regulate T cell function by binding to B7-H4, but further studies are needed to confirm. The existence of three distinct BTLA alleles has been reported.
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基因ID
- 208154
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UniProt
- Q7TSA3
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途径
- Cancer Immune Checkpoints
抗原
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