Recombinant PD-L1 抗体 (C-Term)
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- 抗原 See all PD-L1 抗体
- PD-L1 (CD274 (PD-L1))
- 抗体类型
- Recombinant Antibody
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抗原表位
- C-Term
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适用
- 人
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宿主
- 兔
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克隆类型
- 单克隆
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标记
- This PD-L1 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunoprecipitation (IP), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (fixed cells) (IF/ICC), Multiplex Immunofluorescence (mIF), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))
- 原理
- Rabbit anti-PD-L1 Recombinant Monoclonal Antibody [BLR020E]
- 免疫原
- between AA 250 to 290 (C-term)
- 克隆位点
- BLR020E
- 亚型
- IgG
- Top Product
- Discover our top product PD-L1 Primary Antibody
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- 应用备注
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ICC-IF: 1:100 - 1:500. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE cell sections.
IHC-IF: 1:100 - 1:500. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.
IHC: 1:100 - 1:500. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.
IP: 20 μL/mg lysate
WB: 17:40:00
- 限制
- 仅限研究用
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- 浓度
- 50 μg/mL
- 缓冲液
- Borate Buffered Saline (BBS) pH 8.2 with 0.1 % BSA and 0.09 % Sodium Azide
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C
- 有效期
- 12 months
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- 抗原
- PD-L1 (CD274 (PD-L1))
- 别名
- PD-L1 (PD-L1 产品)
- 背景
- Background: PD-L1 is an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. PD-L1 is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Expression of this gene in tumor cells is considered to be prognostic in many types of human malignancies, including colon cancer and renal cell carcinoma [taken from NCBI Entrez Gene (Gene ID: 55193)].
- 基因ID
- 29126
- NCBI登录号
- NP_054862
- UniProt
- Q9NZQ7
- 途径
- Cancer Immune Checkpoints
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