Recombinant ZEB1 抗体 (AA 750-800)
Quick Overview for Recombinant ZEB1 抗体 (AA 750-800) (ABIN7455173)
抗原
See all ZEB1 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 750-800
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原理
- Rabbit anti-ZEB1 Recombinant Monoclonal Antibody [BLR217K]
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免疫原
- between AA 750 and 800
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亚型
- IgG
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应用备注
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IHC: 1:100 to 1:500. Epitope retrieval with citrate Buffer pH 6.0 is recommended for FFPE tissue sections.
IP: 6 μL/1 mg lysate
ICC: 1:100 to 1:500. Epitope retrieval with citrate Buffer pH 6.0 is recommended for FFPE cell sections.
WB: 01:01,00
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限制
- 仅限研究用
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浓度
- 1000 μg/mL
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缓冲液
- Borate Buffered Saline (BBS) pH 8.2 with 0.09 % Sodium Azide, BSA-Free
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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有效期
- 12 months
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- ZEB1 (Zinc Finger E-Box Binding Homeobox 1 (ZEB1))
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别名
- ZEB1
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背景
- Background: ZEB1 (zinc-finger E-box-binding homeobox 1), also known as TCF8 (transcription factor 8), is a delta-EF1/ZFH-1 C2H2-type zinc finger that bears seven C2H2-type zinc fingers and one homeobox DNA-binding domain. ZEB1 is a transcriptional repressor of interleukin-2 (IL-2). Mutations in the ZEB1 gene are associated with posterior corneal dystrophy type 3 (PPC3) a rare disorder characterized by metaplasia and overgrowth of corneal endothelial cells. ZEB1 appears to be critical to epithelial to mesenchymal transitions (EMT) during development and cancer metastasis. As a transcription factor involved in EMT, ZEB1 promotes EMT by repressing genes associated with the epithelial phenotype and activates genes associated with the mesenchymal phenotype.
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基因ID
- 6935
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NCBI登录号
- NP_001167567
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UniProt
- P37275
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途径
- Regulation of Muscle Cell Differentiation
抗原
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