PSME3 抗体 (AA 204-254)
Quick Overview for PSME3 抗体 (AA 204-254) (ABIN7454979)
抗原
See all PSME3 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 204-254
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原理
- Rabbit anti-PSME3 Antibody, Affinity Purified
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预测反应
- Chicken,Pig,Orangutan
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纯化方法
- Affinity Purified
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免疫原
- Between AA 204 and 254
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亚型
- IgG
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应用备注
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IHC: 1:500 - 1:2,000. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.
IP: 2 - 10 μg/mg lysate
WB: 1:500 - 1:2,500
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限制
- 仅限研究用
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浓度
- 1000 μg/mL
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缓冲液
- Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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有效期
- 12 months
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- PSME3
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别名
- PSME3
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背景
- Background: The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits, 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. The immunoproteasome contains an alternate regulator, referred to as the 11S regulator or PA28, that replaces the 19S regulator. Three subunits (alpha, beta and gamma) of the 11S regulator have been identified. PSME3 [proteasome (prosome, macropain) activator subunit 3 (PA28 gamma, Ki)] is the gamma subunit of the 11S regulator [taken from NCBI Entrez Gene (Gene ID: 10197)].
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基因ID
- 10197
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NCBI登录号
- NP_005780
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UniProt
- P61289
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途径
- Mitotic G1-G1/S Phases, DNA Replication, Positive Regulation of Endopeptidase Activity, Hepatitis C, Synthesis of DNA
抗原
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