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SENP3 抗体 (AA 1-50)

This anti-SENP3 antibody is a 兔 多克隆 antibody detecting SENP3 in WB, IP 和 IHC (fp). Suitable for 人 和 小鼠.
产品编号 ABIN7454899
发货至: 中国

Quick Overview for SENP3 抗体 (AA 1-50) (ABIN7454899)

抗原

See all SENP3 抗体
SENP3 (SUMO/sentrin Specific Peptidase 3 (SENP3))

适用

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人, 小鼠

宿主

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  • 1

克隆类型

  • 33
多克隆

标记

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This SENP3 antibody is un-conjugated

应用范围

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Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))
  • 抗原表位

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    AA 1-50

    原理

    Rabbit anti-SENP3 Antibody, Affinity Purified

    纯化方法

    Affinity Purified

    免疫原

    between AA 1 and 50

    亚型

    IgG
  • 应用备注

    IHC: 1:500 - 1:2,000. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

    IP: 2 - 10 μg/mg lysate

    WB: 1:2,000 - 1:10,000

    限制

    仅限研究用
  • 浓度

    1000 μg/mL

    缓冲液

    Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C

    有效期

    12 months
  • 抗原

    SENP3 (SUMO/sentrin Specific Peptidase 3 (SENP3))

    别名

    SENP3

    背景

    Background: Sentrin-specific protease 3 (SENP3) functions as a protease that releases SUMO2 and SUMO3 monomers from sumoylated substrates, but has only weak activity against SUMO1 conjugates.SENP3 deconjugates SUMO2 from MEF2D, which increases its transcriptional activation capability, and also deconjugates SUMO2 and SUMO3 from CDCA8. SENP3 can function as a redox sensor that, when redistributed into nucleoplasm, can act as an effector to enhance HIF1A transcriptional activity by desumoylating EP300. SENP3 is required for rRNA processing through deconjugation of SUMO2 and SUMO3 from nucleophosmin, NPM1 [taken from the Universal Protein Resource (UniProt) Q9H4L4].

    基因ID

    26168

    NCBI登录号

    NP_056485

    UniProt

    Q9H4L4
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