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ZEB1 抗体 (AA 1074-1124)

This anti-ZEB1 antibody is a 兔 多克隆 antibody detecting ZEB1 in WB, IP 和 IHC (fp). Suitable for 人 和 小鼠.
产品编号 ABIN7454797
发货至: 中国
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中国
北京 101111
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Beijing Economic Technological Development Area
Room 801-803
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Tel +86 (0512) 65829739 传真 +86 (010) 6788 5057

Quick Overview for ZEB1 抗体 (AA 1074-1124) (ABIN7454797)

抗原

See all ZEB1 抗体
ZEB1 (Zinc Finger E-Box Binding Homeobox 1 (ZEB1))

适用

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人, 小鼠

宿主

  • 44
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  • 1

克隆类型

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多克隆

标记

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This ZEB1 antibody is un-conjugated

应用范围

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Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))
  • 抗原表位

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    AA 1074-1124

    原理

    Rabbit anti-ZEB1 Antibody, Affinity Purified

    纯化方法

    Affinity Purified

    免疫原

    between AA 1074 and 1124

    亚型

    IgG
  • 应用备注

    IHC: 1:200 - 1:1000. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

    IP: 2 - 10 μg/mg lysate

    WB: 1:2,000 - 1:10,000

    限制

    仅限研究用
  • 浓度

    200 μg/mL

    缓冲液

    Tris-buffered Saline containing 0.1 % BSA and 0.09 % Sodium Azide

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C

    有效期

    12 months
  • 抗原

    ZEB1 (Zinc Finger E-Box Binding Homeobox 1 (ZEB1))

    别名

    ZEB1

    背景

    Background: ZEB1 (zinc-finger E-box-binding homeobox 1), also known as TCF8 (transcription factor 8), is a delta-EF1/ZFH-1 C2H2-type zinc finger that bears seven C2H2-type zinc fingers and one homeobox DNA-binding domain. ZEB1 is a transcriptional repressor of interleukin-2 (IL-2). Mutations in the ZEB1 gene are associated with posterior corneal dystrophy type 3 (PPC3) a rare disorder characterized by metaplasia and overgrowth of corneal endothelial cells. ZEB1 appears to be critical to epithelial to mesenchymal transitions (EMT) during development and cancer metastasis. As a transcription factor involved in EMT, ZEB1 promotes EMT by repressing genes associated with the epithelial phenotype and activates genes associated with the mesenchymal phenotype.

    基因ID

    6935

    NCBI登录号

    NP_110378

    UniProt

    P37275

    途径

    Regulation of Muscle Cell Differentiation
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