PML 抗体 (AA 575-625)
Quick Overview for PML 抗体 (AA 575-625) (ABIN7454723)
抗原
See all PML 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 575-625
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原理
- Rabbit anti-PML Antibody, Affinity Purified
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纯化方法
- Affinity Purified
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免疫原
- between AA 575 and 625
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亚型
- IgG
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应用备注
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IHC: 1:200 - 1:1,000. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.
IP: 2 - 5 μg/mg lysate
WB: 1:2,000 - 1:10,000
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限制
- 仅限研究用
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浓度
- 200 μg/mL
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缓冲液
- Tris-buffered Saline containing 0.1 % BSA and 0.09 % Sodium Azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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有效期
- 12 months
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- PML (Promyelocytic Leukemia (PML))
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别名
- PML
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背景
- Background: PML is a member of RBCC/TRIM family of proteins that possess a RING finger domain, B-box, and coiled-coil domain. PML is a multifunctional protein involved in activities such as tumor growth suppression, hematopoietic differentiation, gene transcription, apoptotic induction, and viral immunity. PML is often involved in chromosomal translocations with the retinoic acid receptor alpha gene. PML-retinoic acid receptor translocations are associated with acute promyelocytic leukemia.
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基因ID
- 5371
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NCBI登录号
- NP_150241
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UniProt
- P29590
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途径
- p53 Pathway, Retinoic Acid Receptor Signaling Pathway, Maintenance of Protein Location, Positive Regulation of Endopeptidase Activity, Protein targeting to Nucleus
抗原
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