AKAP8 抗体 (C-Term)
Quick Overview for AKAP8 抗体 (C-Term) (ABIN7454715)
抗原
See all AKAP8 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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原理
- Rabbit anti-AKAP8/AKAP95 Antibody, Affinity Purified
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纯化方法
- Affinity Purified
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免疫原
- between AA 642 and C-term
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亚型
- IgG
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应用备注
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IHC: 1:200 - 1:1,000. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.
IP: 2 - 5 μg/mg lysate
WB: 1:2,000 - 1:10,000
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限制
- 仅限研究用
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浓度
- 200 μg/mL
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缓冲液
- Tris-buffered Saline containing 0.1 % BSA and 0.09 % Sodium Azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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有效期
- 12 months
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- AKAP8 (A Kinase (PRKA) Anchor Protein 8 (AKAP8))
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别名
- AKAP8/AKAP95
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背景
- Background: AKAP8/AKAP95 has been characterized as a 95 kDa protein kinase A (PKA)-anchoring protein and regulatory subunit of PKA that functions to recruit the condensin complex for chromosome condensation during mitosis. A role in DNA replication has also been demonstrated through its interaction with the pre-replication complex component, MCM2 (mini-chromosome maintenance 2). Inhibition of AKAP8/AKAP95 association with MCM2 inhibits replication initiation and elongation in vitro. AKAP8/AKAP95 has also been shown to be involved in apoptosis. KAP8/AKAP95 associates with caspase 3 and serves as a carrier to transport caspase 3 from the cytoplasm to the nucleus to induce morphological changes in the nucleus.
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基因ID
- 10270
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NCBI登录号
- NP_005849
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UniProt
- O43823
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途径
- SARS-CoV-2 Protein Interactome
抗原
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