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WWOX 抗体 (AA 364-414)

This anti-WWOX antibody is a 兔 多克隆 antibody detecting WWOX in IP 和 IHC (fp). Suitable for 人.
产品编号 ABIN7454501
发货至: 中国

Quick Overview for WWOX 抗体 (AA 364-414) (ABIN7454501)

抗原

See all WWOX 抗体
WWOX (WW Domain Containing Oxidoreductase (WWOX))

适用

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宿主

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克隆类型

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  • 2
多克隆

标记

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This WWOX antibody is un-conjugated

应用范围

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Immunoprecipitation (IP), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))
  • 抗原表位

    • 12
    • 9
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    • 2
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    AA 364-414

    原理

    Rabbit anti-WWOX Antibody, Affinity Purified

    预测反应

    Orangutan

    纯化方法

    Affinity Purified

    免疫原

    Between AA 364 and 414

    亚型

    IgG
  • 应用备注

    IHC: 1:500 - 1:2,000. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

    IP: 2 - 10 μg/mg lysate

    WB: Not recommended. A304-079A has not performed satisfactorily when used for WB of WWOX in crude preparations (e.g. whole cell lysate). This antibody can be used for WB of enriched (e.g. immunoprecipitated) sources of WWOX.

    限制

    仅限研究用
  • 浓度

    1000 μg/mL

    缓冲液

    Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C

    有效期

    12 months
  • 抗原

    WWOX (WW Domain Containing Oxidoreductase (WWOX))

    别名

    WWOX

    背景

    Background: WW domain-containing oxidoreductase (WWOX) is a putative oxidoreductase, acts as a tumor suppressor, plays a role in apoptosis, and is required for normal bone development (by similarity). WWOX may function synergistically with p53/TP53 to control genotoxic stress-induced cell death. It plays a role in TGFB1 signaling and TGFB1-mediated cell death and may also play a role in tumor necrosis factor (TNF)-mediated cell death. WWOX inhibits Wnt signaling, probably by sequestering DVL2 in the cytoplasm [taken from the Universal Protein Resource (UniProt) Q9NZC7].

    基因ID

    51741

    UniProt

    Q9NZC7
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