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Recombinant UBQLN4 抗体 (AA 2-601)

The 兔 单克隆 anti-UBQLN4 antibody is suitable to detect UBQLN4 in samples from 人. It has been validated for WB, IHC, IP, FACS 和 ICC.
产品编号 ABIN7453990
发货至: 中国
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中国
北京 101111
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Beijing Economic Technological Development Area
Room 801-803
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Quick Overview for Recombinant UBQLN4 抗体 (AA 2-601) (ABIN7453990)

抗原

See all UBQLN4 抗体
UBQLN4 (Ubiquilin 4 (UBQLN4))

抗体类型

Recombinant Antibody

适用

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宿主

  • 13

克隆类型

  • 12
  • 1
单克隆

标记

  • 13
This UBQLN4 antibody is un-conjugated

应用范围

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Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), Flow Cytometry (FACS), Immunocytochemistry (ICC)

克隆位点

BLR145J
  • 抗原表位

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    AA 2-601

    原理

    Rabbit anti-UBQLN4/CIP75/Ubiquilin 4 Recombinant Monoclonal Antibody [BLR145J] - BSA-Free

    纯化方法

    Purified

    免疫原

    residues 2-601 (full length)

    亚型

    IgG
  • 应用备注

    Optimal working dilution should be determined by the investigator.

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    1000 μg/mL

    缓冲液

    Borate Buffered Saline (BBS) pH 8.2 with 0.09 % Sodium Azide, BSA-Free

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C

    储存方法

    2 - 8 °C

    有效期

    12 months
  • 抗原

    UBQLN4 (Ubiquilin 4 (UBQLN4))

    别名

    UBQLN4/CIP75/Ubiquilin 4

    背景

    Ubiquilin-4 (UBQLN4) plays a role in the regulation of protein degradation via the ubiquitin-proteasome system (UPS). It mediates the proteasomal targeting of misfolded or accumulated proteins for degradation by binding (via UBA domain) to their polyubiquitin chains and by interacting (via ubiquitin-like domain) with the subunits of the proteasome. UBQLN4 Plays a role in the regulation of the proteasomal degradation of non-ubiquitinated GJA1 (By similarity). It acts as an adapter protein that recruits UBQLN1 to the autophagy machinery and mediates the association of UBQLN1 with autophagosomes and the autophagy-related protein LC3 (MAP1LC3A/B/C) and may assist in the maturation of autophagosomes to autolysosomes by mediating autophagosome-lysosome fusion (PubMed:23459205) [taken from NCBI Entrez Gene (Gene ID: 56893)].

    基因ID

    56893

    UniProt

    Q9NRR5
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