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Recombinant TFEB 抗体 (AA 426-476)

This anti-TFEB antibody is a 兔 单克隆 antibody detecting TFEB in WB 和 IP. Suitable for 人 和 小鼠.
产品编号 ABIN7453326
发货至: 中国

Quick Overview for Recombinant TFEB 抗体 (AA 426-476) (ABIN7453326)

抗原

See all TFEB 抗体
TFEB (Transcription Factor EB (TFEB))

抗体类型

Recombinant Antibody

适用

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  • 31
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人, 小鼠

宿主

  • 59
  • 7
  • 1

克隆类型

  • 60
  • 6
单克隆

标记

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  • 1
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This TFEB antibody is un-conjugated

应用范围

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  • 36
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  • 4
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  • 1
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Western Blotting (WB), Immunoprecipitation (IP)

克隆位点

BLR070G
  • 抗原表位

    • 16
    • 10
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    • 2
    • 2
    • 2
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    • 1
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    AA 426-476

    原理

    Rabbit anti-TFEB Recombinant Monoclonal Antibody [BLR070G]

    免疫原

    between AA 426 and 476 (C-term)

    亚型

    IgG
  • 应用备注

    IP: 20 μL/1 mg lysate

    WB: 17:40:00

    限制

    仅限研究用
  • 浓度

    100 μg/mL

    缓冲液

    Borate Buffered Saline (BBS) pH 8.2 with 0.1 % BSA and 0.09 % Sodium Azide

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C

    有效期

    12 months
  • 抗原

    TFEB (Transcription Factor EB (TFEB))

    别名

    TFEB

    背景

    Background: Transcription factor EB (TFEB) specifically recognizes and binds E-box sequences (3'-CANNTG-5'). Efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFE3 or MITF. In association with TFE3, TFEB activates the expression of CD40L in T-cells, thereby playing a role in T-cell-dependent antibody responses in activated CD4+ T-cells and thymus-dependent humoral immunity. TFEB specifically recognizes and binds the CLEAR-box sequence (5'-GTCACGTGAC-3') present in the regulatory region of many lysosomal genes, leading to activate their expression, thus, TFEB plays a central role in expression of lysosomal genes. TFEB also specifically recognizes the gamma-E3 box, a subset of E-boxes, present in the heavy-chain immunoglobulin enhancer [taken from the Universal Protein Resource (UniProt) P19484].

    基因ID

    7942

    NCBI登录号

    NP_009093

    UniProt

    P19484
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