TBC1D23 抗体 (AA 525-575)
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北京 101111
Quick Overview for TBC1D23 抗体 (AA 525-575) (ABIN7452842)
抗原
适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 525-575
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原理
- Rabbit anti-TBC1D23 Antibody, Affinity Purified
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预测反应
- Mouse,Zebrafish,X. laevis,Chicken,Orangutan
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纯化方法
- Affinity Purified
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免疫原
- between AA 525 and 575
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亚型
- IgG
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anti-TBC1 Domain Family, Member 23 (TBC1D23) (Internal Region) antibody
TBC1D23 适用: 人, 小鼠, 大鼠 WB, IHC, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-TBC1 Domain Family, Member 23 (TBC1D23) (AA 510-605) antibodyTBC1D23 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-TBC1 Domain Family, Member 23 (TBC1D23) antibodyTBC1D23 适用: 人 WB, FACS 宿主: 小鼠 Monoclonal 25GB8500 unconjugated
anti-TBC1 Domain Family, Member 23 (TBC1D23) (C-Term) antibodyTBC1D23 适用: 人, 小鼠, 大鼠, 豚鼠, Cow, 犬, 马, 兔, 斑马鱼 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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IP: 50-100 μL/mg lysate
WB: 1:10,000 - 1:25,000
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限制
- 仅限研究用
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浓度
- 1000 μg/mL
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缓冲液
- Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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有效期
- 12 months
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- TBC1D23 (TBC1 Domain Family, Member 23 (TBC1D23))
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别名
- TBC1D23
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背景
- Background: TBC1D23 is a putative Rab GTPase-activating protein which plays a role in vesicular trafficking and is involved in endosome-to-Golgi trafficking. Acts as a bridging protein by binding simultaneously to golgins, including GOLGA1 and GOLGA4, located at the trans-Golgi, and to the WASH complex, located on endosome-derived vesicles. Together with WDR11 complex facilitates the golgin-mediated capture of vesicles generated using AP-1. TBC1D23 also plays a role in brain development, including in cortical neuron positioning. May also be important for neurite outgrowth, possibly through its involvement in membrane trafficking and cargo delivery, 2 processes that are essential for axonal and dendritic growth. May act as a general inhibitor of innate immunity signaling, strongly inhibiting multiple TLR and dectin/CLEC7A-signaling pathways. Does not alter initial activation events, but instead affects maintenance of inflammatory gene expression several hours after bacterial lipopolysaccharide (LPS) challenge. [taken from the Universal Protein Resource (UniProt) Q9NUY8].
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基因ID
- 55773
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UniProt
- Q9NUY8
抗原
-
