DKC1 抗体 (AA 390-440)
Quick Overview for DKC1 抗体 (AA 390-440) (ABIN7452755)
抗原
See all DKC1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 390-440
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原理
- Rabbit anti-DKC1 Antibody, Affinity Purified
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纯化方法
- Affinity Purified
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免疫原
- between AA 390 and 440
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亚型
- IgG
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应用备注
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IP: 5 - 15 μg/mg lysate
WB: 1:2,000 - 1:10,000
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限制
- 仅限研究用
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浓度
- 200 μg/mL
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缓冲液
- Tris-buffered Saline containing 0.1 % BSA and 0.09 % Sodium Azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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有效期
- 12 months
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- DKC1 (Dyskeratosis Congenita 1, Dyskerin (DKC1))
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别名
- DKC1
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背景
- Background: Dyskeratosis congenita 1(DKC1) is also known as dyskerin. DKC1 is required for ribosome biogenesis and telomere maintenance. It is a probable catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. DKC1 is also required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme. Defects in DKC1 are a cause of dyskeratosis congenita X-linked recessive (XDKC), a rare progressive bone marrow failure syndrome [taken from the Universal Protein Resource (UniProt) O60832].
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基因ID
- 1736
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NCBI登录号
- NP_001354
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UniProt
- O60832
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途径
- Telomere Maintenance
抗原
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