SUFUH 抗体 (AA 325-375)
Quick Overview for SUFUH 抗体 (AA 325-375) (ABIN7452445)
抗原
See all SUFUH 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 325-375
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原理
- Rabbit anti-SuFu Antibody, Affinity Purified
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纯化方法
- Affinity Purified
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免疫原
- between AA 325 and 375
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亚型
- IgG
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应用备注
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IP: 2 - 5 μg/mg lysate
WB: Not recommended. Use rabbit anti-SuFu antibody ABIN7452074.
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限制
- 仅限研究用
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浓度
- 1000 μg/mL
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缓冲液
- Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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有效期
- 12 months
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- SUFUH (Suppressor of Fused Homolog (SUFUH))
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别名
- SuFu
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背景
- Background: Suppressor of fused (SuFu) is a negative regulator of the hedgehog and beta-catenin signaling pathway. It down-regulates GLI1-mediated transactivation of target genes and is part of a corepressor complex that acts on DNA-bound GLI1. SuFu may also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Additionally, SuFu sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein [taken from the Universal Protein Resource (UniProt) Q9UMX1].
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基因ID
- 51684
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NCBI登录号
- NP_057253
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UniProt
- Q9UMX1
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途径
- Hedgehog Signaling, Tube Formation, Maintenance of Protein Location
抗原
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