DDX3X 抗体 (AA 550-600)
Quick Overview for DDX3X 抗体 (AA 550-600) (ABIN7452202)
抗原
See all DDX3X 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 550-600
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原理
- Rabbit anti-DDX3 Antibody, Affinity Purified
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预测反应
- Mouse
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纯化方法
- Affinity Purified
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免疫原
- between AA 550 and 600
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亚型
- IgG
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应用备注
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IP: 2 - 5 μg/mg lysate
WB: 1:5,000 - 1:15,000
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限制
- 仅限研究用
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浓度
- 1000 μg/mL
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缓冲液
- Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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有效期
- 12 months
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- DDX3X (DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 3, X-Linked (DDX3X))
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别名
- DDX3
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背景
- Background: DDX3 is a member of the DEAD box family of proteins that possesses several conserved motifs which include the highly conserved DEAD (Asp-Glu-Ala-Asp) amino acid sequence motif. The major activity of DEAD box proteins is to function as ATP-dependent RNA helicases. As helicases, DEAD proteins play an important role in all aspects of RNA metabolism and function which include pre-mRNA splicing, RNA synthesis, RNA degradation, RNA export, RNA translation, RNA secondary structure formation, ribosome biogenesis, and the assembly of RNP complexes. DDX3 exhibits a variety of functions. DDX3 is a candidate tumor suppressor that suppresses tumor growth and transcriptionally activates the p21 promoter. DDX3 has been shown to play a role in translation as an eIF4E inhibitory protein that regulates translation initiation. These findings, as well as the observation that DDX3 is regulated by hepatitis C virus and is down-regulated in hepatocellular carcinoma, suggest an important role for DDX3 in growth-regulatory functions.
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基因ID
- 1654
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NCBI登录号
- NP_001347
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UniProt
- O00571
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途径
- Ribonucleoprotein Complex Subunit Organization, Positive Regulation of Endopeptidase Activity, Negative Regulation of intrinsic apoptotic Signaling, Ribosome Assembly
抗原
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