ZEB1 抗体 (AA 850-900)
Quick Overview for ZEB1 抗体 (AA 850-900) (ABIN7452186)
抗原
See all ZEB1 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- AA 850-900
-
原理
- Rabbit anti-ZEB1 Antibody, Affinity Purified
-
纯化方法
- Affinity Purified
-
免疫原
- between AA 850 and 900
-
亚型
- IgG
-
-
-
-
应用备注
-
IP: 2 - 5 μg/mg lysate
WB: 1:2,000 - 1:10,000
-
限制
- 仅限研究用
-
-
-
浓度
- 200 μg/mL
-
缓冲液
- Tris-buffered Saline containing 0.1 % BSA and 0.09 % Sodium Azide
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- 4 °C
-
有效期
- 12 months
-
-
- ZEB1 (Zinc Finger E-Box Binding Homeobox 1 (ZEB1))
-
别名
- ZEB1
-
背景
- Background: ZEB1 (zinc-finger E-box-binding homeobox 1), also known as TCF8 (transcription factor 8), is a delta-EF1/ZFH-1 C2H2-type zinc finger that bears seven C2H2-type zinc fingers and one homeobox DNA-binding domain. ZEB1 is a transcriptional repressor of interleukin-2 (IL-2). Mutations in the ZEB1 gene are associated with posterior corneal dystrophy type 3 (PPC3) a rare disorder characterized by metaplasia and overgrowth of corneal endothelial cells. ZEB1 appears to be critical to epithelial to mesenchymal transitions (EMT) during development and cancer metastasis. As a transcription factor involved in EMT, ZEB1 promotes EMT by repressing genes associated with the epithelial phenotype and activates genes associated with the mesenchymal phenotype.
-
基因ID
- 6935
-
NCBI登录号
- NP_110378
-
UniProt
- P37275
-
途径
- Regulation of Muscle Cell Differentiation
抗原
-