CSK 抗体 (AA 375-425)
Quick Overview for CSK 抗体 (AA 375-425) (ABIN7451223)
抗原
See all CSK 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- AA 375-425
-
原理
- Rabbit anti-CSK Antibody, Affinity Purified
-
预测反应
- Mouse,Rat,Chicken,Bovine
-
纯化方法
- Affinity Purified
-
免疫原
- Between AA 375 and 425
-
亚型
- IgG
-
-
anti-C-Src tyrosine Kinase (CSK) (AA 1-100) antibody
CSK 适用: 人 WB, ELISA, IP, IHC (p), RNAi 宿主: 小鼠 Monoclonal 3A3 unconjugated
anti-C-Src tyrosine Kinase (CSK) (C-Term) antibodyVerified CSK 适用: 人 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-C-Src tyrosine Kinase (CSK) antibodyCSK 适用: 人 WB, IHC 宿主: 兔 Monoclonal unconjugated
anti-C-Src tyrosine Kinase (CSK) antibodyCSK 适用: 人, 小鼠, 大鼠, 猴 WB, ELISA, ICC, FACS 宿主: 小鼠 Monoclonal 5F3 unconjugated
anti-C-Src tyrosine Kinase (CSK) (AA 243-438) antibodyCSK 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-C-Src tyrosine Kinase (CSK) (AA 325-416) antibodyCSK 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-C-Src tyrosine Kinase (CSK) (AA 67-101), (N-Term) antibodyCSK 适用: 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB50568 unconjugated
anti-C-Src tyrosine Kinase (CSK) (Ser280) antibodyCSK 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-C-Src tyrosine Kinase (CSK) (AA 330-450) antibodyCSK 适用: 人, 小鼠 WB, IP, ICC 宿主: 小鼠 Monoclonal CSK-04 unconjugated
anti-C-Src tyrosine Kinase (CSK) (AA 241-450) antibodyCSK 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
-
-
应用备注
-
IP: 2 - 10 μg/mg lysate
WB: Not recommended. Use rabbit anti-CSK antibody ABIN7450141.
-
限制
- 仅限研究用
-
-
-
浓度
- 1000 μg/mL
-
缓冲液
- Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- 4 °C
-
有效期
- 12 months
-
-
- CSK (C-Src tyrosine Kinase (CSK))
-
别名
- CSK
-
背景
- Background: C-Src kinase (CSK) is a non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response. CSK phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases (SFKs) including LCK, SRC, HCK, FYN, LYN or YES1. Upon tail phosphorylation, Src-family members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins or adapter proteins located near the plasma membrane. CSK suppresses signaling by various surface receptors, including T-cell receptor (TCR) and B-cell receptor (BCR) by phosphorylating and maintaining inactive several positive effectors such as FYN or LCK [taken from the Universal Protein Resource (UniProt) P41240].
-
基因ID
- 1445
-
NCBI登录号
- NP_004374
-
UniProt
- P41240
-
途径
- TCR Signaling, EGFR Signaling Pathway, Cell-Cell Junction Organization, CXCR4-mediated Signaling Events
抗原
-
