Neurofibromin 1 抗体 (AA 150-200)
Quick Overview for Neurofibromin 1 抗体 (AA 150-200) (ABIN7451098)
抗原
See all Neurofibromin 1 (NF1) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 150-200
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原理
- Rabbit anti-NF1 Antibody, Affinity Purified
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预测反应
- Mouse,Rat
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纯化方法
- Affinity Purified
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免疫原
- Between AA 150 and 200
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亚型
- IgG
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应用备注
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IP: 2 - 10 μg/mg lysate
WB: Not recommended. ABIN7451098 has not performed satisfactorily when used for WB of NF1 in crude preparations (e.g. whole cell lysate). This antibody can be used for WB of enriched (e.g. immunoprecipitated) sources of NF1.
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限制
- 仅限研究用
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浓度
- 1000 μg/mL
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缓冲液
- Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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有效期
- 12 months
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- Neurofibromin 1 (NF1)
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别名
- NF1
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背景
- Background: Inactivating mutations in NF1 (neurofibromin 1) result in neurofibromatosis type I (NF1) which is characterized by Schwann cell neurofibromas, café-au-lait spots, and benign lesions of the iris. At the cellular level, NF1 functions as a negative regulator of Ras activity. Loss of NF1 leads to increased levels of active Ras-GTP which is important for the formation and maintenance of Schwann cell tumors.
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基因ID
- 4763
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NCBI登录号
- NP_001035957
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UniProt
- P21359
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途径
- cAMP Metabolic Process, Regulation of long-term Neuronal Synaptic Plasticity
抗原
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