VRK1 抗体 (AA 346-396)
Quick Overview for VRK1 抗体 (AA 346-396) (ABIN7450901)
抗原
See all VRK1 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- AA 346-396
-
原理
- Rabbit anti-VRK1 Antibody, Affinity Purified
-
纯化方法
- Affinity Purified
-
免疫原
- Between AA 346 and 396
-
亚型
- IgG
-
-
-
-
应用备注
-
IP: 2 - 10 μg/mg lysate
WB: 1:2,000 - 1:10,000
-
限制
- 仅限研究用
-
-
-
浓度
- 1000 μg/mL
-
缓冲液
- Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- 4 °C
-
有效期
- 12 months
-
-
- VRK1 (Vaccinia Related Kinase 1 (VRK1))
-
别名
- VRK1
-
背景
- Background: Vaccinia-related kinase 1 is a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases.VRK1 is widely expressed in human tissues and has increased expression in actively dividing cells, such as those in testis, thymus, fetal liver, and carcinomas. Its protein localizes to the nucleus and has been shown to promote the stability and nuclear accumulation of a transcriptionally active p53 Molecule and, in vitro, to phosphorylate Thr18 of p53 and reduce p53 ubiquitination. This protein, therefore, may regulate cell proliferation. This protein also phosphorylates histone, casein, and the transcription factors ATF2 (activating transcription factor 2) and c-JUN [taken from NCBI Entrez Gene (Gene ID: 7443)].
-
基因ID
- 7443
-
UniProt
- Q99986
抗原
-