SBDS 抗体 (AA 175-225)
Quick Overview for SBDS 抗体 (AA 175-225) (ABIN7450730)
抗原
See all SBDS 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 175-225
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原理
- Rabbit anti-Shwachman-Bodian-Diamond Syndrome/SBDS Antibody, Affinity Purified
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预测反应
- Bovine,Orangutan
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纯化方法
- Affinity Purified
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免疫原
- Between AA 175 and 225
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亚型
- IgG
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应用备注
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IP: 2 - 10 μg/mg lysate
WB: 1:2,000 - 1:10,000
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限制
- 仅限研究用
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浓度
- 1000 μg/mL
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缓冲液
- Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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有效期
- 12 months
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- SBDS (Shwachman-Bodian-Diamond Syndrome (SBDS))
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别名
- Shwachman-Bodian-Diamond Syndrome/SBDS
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背景
- Background: Shwachman-Bodian-Diamond Syndrome/SBDS is required for the assembly of mature ribosomes and ribosome biogenesis. Together with EFTUD1, it triggers the GTP-dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. SBDS is required for normal levels of protein synthesis. It may play a role in cellular stress resistance and cellular response to DNA damage. It may also play a role in cell proliferation [taken from the Universal Protein Resource (UniProt) Q9Y3A5].
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基因ID
- 51119
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UniProt
- Q9Y3A5
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途径
- Ribonucleoprotein Complex Subunit Organization, Ribosome Assembly
抗原
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