PAN2 抗体 (AA 1-50)
Quick Overview for PAN2 抗体 (AA 1-50) (ABIN7450538)
抗原
See all PAN2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1-50
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原理
- Rabbit anti-PAN2/USP52 Antibody, Affinity Purified
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预测反应
- Rat
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纯化方法
- Affinity Purified
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免疫原
- Between AA 1 and 50
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亚型
- IgG
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anti-PAN2 Poly(A) Specific Ribonuclease Subunit Homolog (PAN2) (AA 628-908) antibody
PAN2 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-PAN2 Poly(A) Specific Ribonuclease Subunit Homolog (PAN2) (AA 1099-1198) antibodyPAN2 适用: 人 ELISA, WB, IF 宿主: 小鼠 Monoclonal 6A7 unconjugated
anti-PAN2 Poly(A) Specific Ribonuclease Subunit Homolog (PAN2) (AA 700-1000) antibodyPAN2 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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IP: 2 - 10 μg/mg lysate
WB: 1:2,000 - 1:10,000
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限制
- 仅限研究用
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浓度
- 1000 μg/mL
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缓冲液
- Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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有效期
- 12 months
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- PAN2 (PAN2 Poly(A) Specific Ribonuclease Subunit Homolog (PAN2))
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别名
- PAN2/USP52
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背景
- Background: PAB-dependent poly(A)-specific ribonuclease subunit PAN2 is the catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA when the poly(A) stretch is bound by poly(A)-binding protein (PABP), which is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1 [taken from the Universal Protein Resource (UniProt) Q504Q3].
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基因ID
- 9924
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UniProt
- Q504Q3
抗原
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