LIN28B 抗体 (AA 1-50)
Quick Overview for LIN28B 抗体 (AA 1-50) (ABIN7450415)
抗原
See all LIN28B 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1-50
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原理
- Rabbit anti-LIN28B Antibody, Affinity Purified
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纯化方法
- Affinity Purified
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免疫原
- Between AA 1 and 50
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亚型
- IgG
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应用备注
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IP: 2 - 10 μg/mg lysate
WB: 1:2,000 - 1:10,000
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限制
- 仅限研究用
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浓度
- 200 μg/mL
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缓冲液
- Tris-buffered Saline containing 0.1 % BSA and 0.09 % Sodium Azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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有效期
- 12 months
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- LIN28B (Lin-28 Homolog B (LIN28B))
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别名
- LIN28B
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背景
- Background: Lin-28 homolog B (LIN28B) acts as a suppressor of microRNA (miRNA) biogenesis by specifically binding the precursor let-7 (pre-let-7), a miRNA precursor. LIN28B acts by binding pre-let-7 and recruiting ZCCHC11/TUT4 uridylyltransferase, leading to the terminal uridylation of pre-let-7. LIN28B specifically recognizes the 5'-GGAG-3' motif in the terminal loop of pre-let-7. It also recognizes and binds non pre-let-7 pre-miRNAs that contain the 5'-GGAG-3' motif in the terminal loop, leading to their terminal uridylation and subsequent degradation [taken from the Universal Protein Resource (UniProt) Q6ZN17].
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基因ID
- 389421
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NCBI登录号
- NP_001004317
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UniProt
- Q6ZN17
抗原
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