FERMT2 抗体 (AA 175-225)
Quick Overview for FERMT2 抗体 (AA 175-225) (ABIN7450396)
抗原
See all FERMT2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 175-225
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原理
- Rabbit anti-Kindlin-2 Antibody, Affinity Purified
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纯化方法
- Affinity Purified
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免疫原
- Between AA 175 and 225
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亚型
- IgG
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anti-Fermitin Family Member 2 (FERMT2) antibody
FERMT2 适用: 人, 大鼠, 犬, 猴 WB, IHC, IF, IP, IHC (p) 宿主: 小鼠 Monoclonal 14A11 unconjugated
anti-Fermitin Family Member 2 (FERMT2) (AA 1-680) antibodyFERMT2 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 2G11 unconjugated
anti-Fermitin Family Member 2 (FERMT2) (AA 155-232) antibodyFERMT2 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Fermitin Family Member 2 (FERMT2) (AA 380-550) antibodyFERMT2 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Fermitin Family Member 2 (FERMT2) (C-Term) antibodyFERMT2 适用: 人, 小鼠, 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Fermitin Family Member 2 (FERMT2) (AA 402-451) antibodyFERMT2 适用: 人, Cow, Pig, 兔 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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IP: 2 - 10 μg/mg lysate
WB: 1:2,000 - 1:10,000
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限制
- 仅限研究用
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浓度
- 1000 μg/mL
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缓冲液
- Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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有效期
- 12 months
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- FERMT2 (Fermitin Family Member 2 (FERMT2))
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别名
- Kindlin-2
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背景
- Background: Kindlin-2 is a scaffolding protein that enhances integrin activation mediated by TLN1 and/or TLN2, but activates integrins only weakly by itself. It binds to membranes enriched in phosphoinositides. It also enhances integrin-mediated cell adhesion onto the extracellular matrix and cell spreading, this requires both its ability to interact with integrins and with phospholipid membranes. Kindlin-2 is required for the assembly of focal adhesions and participates in the connection between extracellular matrix adhesion sites and the actin cytoskeleton and also in the orchestration of actin assembly and cell shape modulation. Kindlin-2 recruits FBLIM1 to focal adhesions. It plays a role in the TGFB1 and integrin signaling pathways, and it stabilizes active CTNNB1 and plays a role in the regulation of transcription mediated by CTNNB1 and TCF7L2/TCF4 and in Wnt signaling [taken from the Universal Protein Resource (UniProt) Q96AC1].
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基因ID
- 10979
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NCBI登录号
- NP_006823
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UniProt
- Q96AC1
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途径
- Cell-Cell Junction Organization
抗原
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