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Desmoplakin 抗体 (AA 1600-1650)

This anti-Desmoplakin antibody is a 兔 多克隆 antibody detecting Desmoplakin in WB 和 IP. Suitable for 人.
产品编号 ABIN7450166
发货至: 中国

Quick Overview for Desmoplakin 抗体 (AA 1600-1650) (ABIN7450166)

抗原

See all Desmoplakin (DSP) 抗体
Desmoplakin (DSP)

适用

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宿主

  • 30
  • 6
  • 2
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克隆类型

  • 32
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多克隆

标记

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  • 2
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This Desmoplakin antibody is un-conjugated

应用范围

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Western Blotting (WB), Immunoprecipitation (IP)
  • 抗原表位

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    AA 1600-1650

    原理

    Rabbit anti-Desmoplakin Antibody, Affinity Purified

    纯化方法

    Affinity Purified

    免疫原

    between AA 1600 and 1650

    亚型

    IgG
  • 应用备注

    IP: 2 - 10 μg/mg lysate

    WB: 1:2,000 - 1:10,000

    限制

    仅限研究用
  • 浓度

    1000 μg/mL

    缓冲液

    Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C

    有效期

    12 months
  • 抗原

    Desmoplakin (DSP)

    别名

    Desmoplakin

    背景

    Background: Desmosomes are intercellular junctions that tightly link adjacent cells. Desmoplakin is an obligate component of functional desmosomes that anchors intermediate filaments to desmosomal plaques. The N-terminus of desmoplakin is required for localization to the desmosome and interacts with the N-terminal region of plakophilin 1 and plakoglobin. The C-terminus of desmoplakin binds with intermediate filaments. In the mid-region of desmoplakin, a coiled-coiled rod domain is responsible for homodimerization. Mutations in DSP, the gene encoding desmoplakin, are the cause of several cardiomyopathies and keratodermas as well as the autoimmune disease paraneoplastic pemphigus [taken from NCBI Entrez Gene (Gene ID: 1832)].

    基因ID

    1832

    NCBI登录号

    NP_004406

    UniProt

    P15924

    途径

    Cell-Cell Junction Organization
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