ATF6 抗体 (AA 125-175)
Quick Overview for ATF6 抗体 (AA 125-175) (ABIN7449998)
抗原
See all ATF6 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 125-175
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原理
- Rabbit anti-ATF6 Antibody, Affinity Purified
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纯化方法
- Affinity Purified
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免疫原
- Between AA 125 and 175
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亚型
- IgG
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应用备注
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IP: 2 - 10 μg/mg lysate
WB: 1:2,000 - 1:10,000
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限制
- 仅限研究用
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浓度
- 1000 μg/mL
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缓冲液
- Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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有效期
- 12 months
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- ATF6 (Activating Transcription Factor 6 (ATF6))
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别名
- ATF6
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背景
- Background: Activating transcription factor 6 (ATF6) is a transcription factor that activates target genes for the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Although it is a transcription factor, this protein is unusual in that it is synthesized as a transmembrane protein that is embedded in the ER. It functions as an ER stress sensor/transducer, and following ER stress-induced proteolysis, it functions as a nuclear transcription factor via a cis-acting ER stress response element (ERSE) that is present in the promoters of genes encoding ER chaperones. This protein has been identified as a survival factor for quiescent but not proliferative squamous carcinoma cells [taken from NCBI Entrez Gene (Gene ID: 22926)].
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基因ID
- 22926
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NCBI登录号
- NP_031374
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UniProt
- P18850
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途径
- ER-Nucleus Signaling, Unfolded Protein Response
抗原
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